Kcnn3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnn3provided by MGI
Official Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3provided by MGI
Primary source: MGI:MGI:2153183
See related: Ensembl:ENSMUSG00000000794 AllianceGenome:MGI:2153183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SK3; SKCA3; KCa2.3
Summary: Predicted to enable calmodulin binding activity; inward rectifier potassium channel activity; and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in paranoid schizophrenia and schizophrenia. Orthologous to human KCNN3 (potassium calcium-activated channel subfamily N member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 3.1), bladder adult (RPKM 2.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.16 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89427471..89579801)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89520164..89672494)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking.
Title: Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking.
Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.
Title: Endothelial K(Ca)3.1 and K(Ca)2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.
Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db Mice.
Title: Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db Mice.
Bioinformatics identification and pharmacological validation of Kcnn3/KCa2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice.
Title: Bioinformatics identification and pharmacological validation of Kcnn3/K(Ca)2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice.
AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.
Title: AMPK upregulates K(Ca)2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.
Properties of SK3 channel-expressing PDGFRalpha (+) cells in the rodent urinary bladder
Title: Properties of SK3 channel-expressing PDGFRα (+) cells in the rodent urinary bladder.
Caveolae provide a key microdomain in renal collecting duct cells for coupling of TRPV4 with SK3, IK1, and BK that directly contributes to TRPV4-mediated Ca(2+) signaling in these domains.
Title: Caveolae facilitate TRPV4-mediated Ca(2+) signaling and the hierarchical activation of Ca(2+)-activated K(+) channels in K(+)-secreting renal collecting duct cells.
These findings demonstrate how Ca(2+) influx through TRPV4 channels can activate SK channels in PDGFRalpha(+) cells and prevent bladder overactivity during filling.
Title: Premature contractions of the bladder are suppressed by interactions between TRPV4 and SK3 channels in murine detrusor PDGFRα(+) cells.
the present study shows that KCa2.3 channels are located in the apical plasma membrane of endothelial cells, and occasionally at inter-endothelial junctions of the corpus cavernosum. We found that down-regulation of these channels increases norepinephrine contraction in corpus cavernosum strips, and it seems associated with erectile dysfunction.
Title: Down-regulation of K(Ca)2.3 channels causes erectile dysfunction in mice.
Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability.
Title: Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (4) 1 citation

General gene information

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Markers

G16005 (e-PCR)
- UniSTS:43402

D2Wox58 (e-PCR)
- UniSTS:240055

Stn388 (e-PCR)
- UniSTS:478138

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables small conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small conductance calcium-activated potassium channel protein 3

Names: SKCa 3; small conductance calcium-activated potassium channel 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080466.2 → NP_536714.2 small conductance calcium-activated potassium channel protein 3

See identical proteins and their annotated locations for NP_536714.2

Status: VALIDATED

Source sequence(s)

AC166364, AK137738

Consensus CDS

CCDS38495.1

UniProtKB/Swiss-Prot

P58391, Q3UUY9

UniProtKB/TrEMBL

Q45FA7

Related

ENSMUSP00000000811.8, ENSMUST00000000811.8

Conserved Domains (4) summary

pfam02888
Location:562 → 634

CaMBD; Calmodulin binding domain

pfam03530
Location:274 → 381

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:469 → 548

Ion_trans_2; Ion channel

cl09111
Location:596 → 674

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...