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Plxnb2 plexin B2 [ Mus musculus (house mouse) ]

Gene ID: 140570, updated on 4-Jan-2025

Summary

Official Symbol
Plxnb2provided by MGI
Official Full Name
plexin B2provided by MGI
Primary source
MGI:MGI:2154239
See related
Ensembl:ENSMUSG00000036606 AllianceGenome:MGI:2154239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Debt; plexin-B2
Summary
Enables semaphorin receptor activity. Involved in several processes, including nervous system development; regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within positive regulation of axonogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB2 (plexin B2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in colon adult (RPKM 85.9), ovary adult (RPKM 65.3) and 28 other tissues See more
Orthologs
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Genomic context

See Plxnb2 in Genome Data Viewer
Location:
15 E3; 15 44.68 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89039752..89064960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89155546..89182018, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene DENN domain containing 6B Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene protein phosphatase 6, regulatory subunit 2 Neighboring gene SET binding factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Interactions

General gene information

Clone Names

  • mKIAA0315, 1110007H23Rik

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in brain development PubMed 
involved_in excitatory synapse assembly PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
involved_in negative regulation of cell adhesion  
involved_in neural tube closure PubMed 
involved_in neuroblast proliferation PubMed 
involved_in positive regulation of axonogenesis  
acts_upstream_of_or_within positive regulation of axonogenesis PubMed 
involved_in positive regulation of neuron projection development  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of translation  
involved_in positive regulation of translation  
involved_in regulation of GTPase activity PubMed 
involved_in regulation of cell migration  
involved_in regulation of cell shape  
involved_in regulation of cell shape PubMed 
involved_in regulation of neuron migration PubMed 
involved_in regulation of protein phosphorylation PubMed 
involved_in semaphorin-plexin signaling pathway  
involved_in semaphorin-plexin signaling pathway PubMed 
involved_in synapse assembly  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
part_of semaphorin receptor complex  

General protein information

Preferred Names
plexin-B2
Names
differentially expressed in brain tumors

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159521.3NP_001152993.1  plexin-B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001152993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC113069, AC160538
    Consensus CDS
    CCDS49698.1
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. NM_001284506.2NP_001271435.1  plexin-B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001271435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC113069, AC160538
    Consensus CDS
    CCDS49698.1
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Related
    ENSMUSP00000051731.10, ENSMUST00000060808.10
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  3. NM_001416425.1NP_001403354.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  4. NM_001416426.1NP_001403355.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  5. NM_001416427.1NP_001403356.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  6. NM_001416428.1NP_001403357.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  7. NM_001416429.1NP_001403358.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  8. NM_001416430.1NP_001403359.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  9. NM_001416431.1NP_001403360.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  10. NM_001416432.1NP_001403361.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  11. NM_001416433.1NP_001403362.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  12. NM_001416434.1NP_001403363.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  13. NM_001416435.1NP_001403364.1  plexin-B2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
  14. NM_001416436.1NP_001403365.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
  15. NM_001416437.1NP_001403366.1  plexin-B2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
  16. NM_138749.4NP_620088.2  plexin-B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_620088.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC113069, AC160538
    Consensus CDS
    CCDS49698.1
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Related
    ENSMUSP00000104955.2, ENSMUST00000109331.9
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89039752..89064960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248318.2XP_030104178.1  plexin-B2 isoform X1

    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
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