Apoa5 apolipoprotein A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apoa5provided by RGD
Official Full Name: apolipoprotein A5provided by RGD
Primary source: RGD:70903
See related: Ensembl:ENSRNOG00000018436 AllianceGenome:RGD:70903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: apo-AV; apoA-V
Summary: Predicted to enable several functions, including cholesterol binding activity; enzyme activator activity; and heparin binding activity. Involved in animal organ regeneration; lipid transport; and response to hormone. Located in extracellular space. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in cerebral infarction; coronary artery disease; familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to human APOA5 (apolipoprotein A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 2621.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55446329..55460509)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46561180..46563818)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50559079..50561720)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of ApoA5 and its function in the right ventricular failing and remodeling secondary to pulmonary hypertension.
Title: Expression of ApoA5 and its function in the right ventricular failing and remodeling secondary to pulmonary hypertension.
Our data support the hypothesis that apoA5 promotes hepatic TG storage and therefore contributes to the pathogenesis of non-alcoholic fatty liver disease
Title: Increased apolipoprotein A5 expression in human and rat non-alcoholic fatty livers.
Demonstrate that apoA-V is secreted into bile, introducing a potential route of delivery of hepatic apoA-V to the gut lumen.
Title: Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats.
Upregulation of apoA5 expression contributes to the triglyceridelowering effect of statins via the PPARalpha signaling pathway.
Title: [Statin reduced triglyceride level via activating peroxisome proliferator activated receptor α and upregulating apolipoprotein A5 in hypertriglyceridemic rats].
The increase in apolipoprotein A mRNA induced by rosiglitazone is not directly mediated by peroxisome proliferator-activated receptor gamma.[apolipoprotein av]
Title: Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats.
apoA-V inefficiently traffics within the secretory pathway, that its intracellular itinerary can be regulated by changes in cellular TG accumulation, and that apoA-V synthesis can modulate VLDL TG mobilization and secretion.
Title: Biogenesis of apolipoprotein A-V and its impact on VLDL triglyceride secretion.
decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity
Title: Decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity.
ApoA-V ability to enhance insulin secretion in beta-cells and provide evidence of an internalization pathway involving the midkine as partner.
Title: Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine.
data suggest that the C terminus of apoA-V is essential for lipid droplet association in transfected hepatoma cells and lipoprotein association in conditioned medium while the signal peptide is required for extracellular trafficking of this protein.
Title: Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment.
The absence of significant changes in Apoa5 gene expression during chronic fructose-induced triglyceride elevation excludes its major role in mechanisms compensating severe hypertriglyceridemia
Title: Apolipoprotein A5 and hypertriglyceridemia in Prague hypertriglyceridemic rats.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH139127 (e-PCR)
- UniSTS:221213

AU026411 (e-PCR)
- UniSTS:114306

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables lipase activator activity	ISO Inferred from Sequence Orthology more info
enables lipase binding	IEA Inferred from Electronic Annotation more info
enables lipase binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activator activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activator activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acylglycerol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in acylglycerol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride-rich lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride-rich lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in extracellular vesicle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
NOT part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein A-V

Names: regeneration-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277264.1 → NP_001264193.1 apolipoprotein A-V precursor

See identical proteins and their annotated locations for NP_001264193.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC089780, JAXUCZ010000008

UniProtKB/Swiss-Prot

Q5FVT8, Q9QUH3

UniProtKB/TrEMBL

A0A8I6ASM1

Conserved Domains (1) summary

pfam01442
Location:65 → 242

Apolipoprotein; Apolipoprotein A1/A4/E domain
NM_080576.2 → NP_542143.1 apolipoprotein A-V precursor

See identical proteins and their annotated locations for NP_542143.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC089780

UniProtKB/Swiss-Prot

Q5FVT8, Q9QUH3

UniProtKB/TrEMBL

A0A8I6ASM1

Related

ENSRNOP00000024918.4, ENSRNOT00000024918.6

Conserved Domains (1) summary

pfam01442
Location:65 → 242

Apolipoprotein; Apolipoprotein A1/A4/E domain