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Ap2b1 adaptor related protein complex 2 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140670, updated on 2-May-2024

Summary

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Symbol
Ap2b1provided by RGD
Full Name
adaptor related protein complex 2 subunit beta 1provided by RGD
Primary source
RGD:71048
See related
Ensembl:ENSRNOG00000061543 AllianceGenome:RGD:71048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables clathrin binding activity. Involved in several processes, including clathrin coat assembly; negative regulation of neuron death; and positive regulation of endocytosis. Part of clathrin coat. Biomarker of middle cerebral artery infarction. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 391.0), Brain (RPKM 322.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap2b1 in Genome Data Viewer
Location:
10q26
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68596925..68702547)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68099397..68205023)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70516462..70621973)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S27-like Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. Rudinskiy N, et al. J Biol Chem, 2009 May 1. PMID 19240038, Free PMC Article
  2. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. Fukamachi K, et al. J Biol Chem, 2002 Nov 15. PMID 12297494
  3. The synaptic vesicle cycle: a single vesicle budding step involving clathrin and dynamin. Takei K, et al. J Cell Biol, 1996 Jun. PMID 8682861, Free PMC Article
  4. The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. Gallusser A, et al. EMBO J, 1993 Dec 15. PMID 8262066, Free PMC Article
  5. Conservation and diversity in families of coated vesicle adaptins. Ponnambalam S, et al. J Biol Chem, 1990 Mar 25. PMID 1969413

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARH protein has an AP-2 beta2 appendage-binding sequence
    Title: Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac septum development ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization EXP
Inferred from Experiment
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic neurotransmitter receptor internalization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AP-type membrane coat adaptor complex TAS
Traceable Author Statement
more info
 PubMed 
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin coat IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of presynaptic endocytic zone membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse NAS
Non-traceable Author Statement
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic endocytic zone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic endocytic zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AP-2 complex subunit beta
Names
AP-1 complex subunit beta-1-like
AP-2 complex subunit beta-like
AP105B
adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta
adaptor protein complex AP-2 subunit beta
adaptor-related protein complex 2 subunit beta
adaptor-related protein complex 2, beta 1 subunit
beta-2-adaptin
beta-adaptin
beta2-adaptin
clathrin assembly protein complex 2 beta large chain
plasma membrane adaptor HA2/AP2 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080583.2 → NP_542150.1  AP-2 complex subunit beta

    See identical proteins and their annotated locations for NP_542150.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8L2R7J3, Q3ZB97
    Related
    ENSRNOP00000070905.1, ENSRNOT00000088198.2
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    68596925..68702547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767937.4 → XP_008766159.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766159.1

    UniProtKB/TrEMBL
    A0A8L2R7J3, Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  2. XM_063268347.1 → XP_063124417.1  AP-2 complex subunit beta isoform X2

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    A6HHH4

  3. XM_017596973.3 → XP_017452462.1  AP-2 complex subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8L2R7J3, Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  4. XM_063268345.1 → XP_063124415.1  AP-2 complex subunit beta isoform X2

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    A6HHH4

  5. XM_008767938.3 → XP_008766160.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766160.1

    UniProtKB/TrEMBL
    A0A8L2R7J3, Q3ZB97
    Related
    ENSRNOP00000073619.2
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  6. XM_008767936.4 → XP_008766158.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_008766158.1

    UniProtKB/TrEMBL
    A0A8L2R7J3, Q3ZB97
    Conserved Domains (4) summary
    smart00809
    Location:731 → 831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840 → 950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  7. XM_063268346.1 → XP_063124416.1  AP-2 complex subunit beta isoform X2

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    A6HHH4

  8. XM_008767939.4 → XP_008766161.1  AP-2 complex subunit beta isoform X2

    See identical proteins and their annotated locations for XP_008766161.1

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    A0A8L2R7J3, A6HHH4
    Related
    ENSRNOP00000084537.1
    Conserved Domains (4) summary
    smart00809
    Location:717 → 817
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826 → 936
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  9. XM_063268342.1 → XP_063124412.1  AP-2 complex subunit beta isoform X1

    UniProtKB/TrEMBL
    Q3ZB97

  10. XM_063268348.1 → XP_063124418.1  AP-2 complex subunit beta isoform X2

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    A6HHH4

  11. XM_063268350.1 → XP_063124420.1  AP-2 complex subunit beta isoform X3

  12. XM_063268349.1 → XP_063124419.1  AP-2 complex subunit beta isoform X2

    UniProtKB/Swiss-Prot
    P62944
    UniProtKB/TrEMBL
    A6HHH4

  13. XM_063268343.1 → XP_063124413.1  AP-2 complex subunit beta isoform X1

    UniProtKB/TrEMBL
    Q3ZB97

  14. XM_063268344.1 → XP_063124414.1  AP-2 complex subunit beta isoform X1

    UniProtKB/TrEMBL
    Q3ZB97
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62944.1 GenPept UniProtKB/Swiss-Prot:P62944

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