Caskin1 CASK interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Caskin1provided by RGD
Official Full Name: CASK interacting protein 1provided by RGD
Primary source: RGD:620191
See related: Ensembl:ENSRNOG00000003195 AllianceGenome:RGD:620191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein domain specific binding activity. Involved in signal transduction. Located in cytoplasm. Orthologous to human CASKIN1 (CASK interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 90.1), Testes (RPKM 27.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14016780..14037927)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13512684..13533380)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13853107..13874254)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

proline-rich region of Caskin1 is biochemically functional, as it interacts with the adaptor protein Abl-interactor-2.
Title: High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caskin-1

Names: cask-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080690.2 → NP_542421.2 caskin-1

Status: VALIDATED

Source sequence(s)

AA819372, AF451975, CB733612, CB738051, CB800449, JAXUCZ010000010

UniProtKB/Swiss-Prot

Q8VHK2

UniProtKB/TrEMBL

A0A8J8XK13

Related

ENSRNOP00000004486.2, ENSRNOT00000004486.6

Conserved Domains (12) summary

cd09497
Location:473 → 538

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:540 → 609

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

smart00454
Location:472 → 534

SAM; Sterile alpha motif

cd12062
Location:284 → 345

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

cd00204
Location:43 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:119 → 218

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:7 → 69

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:208 → 261

Ank_5; Ankyrin repeats (many copies)

pfam16600
Location:373 → 421

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1368 → 1430

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:877 → 948

Caskin-Pro-rich; Proline rich region of Caskin proteins

sd00045
Location:114 → 145

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14016780..14037927

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245895.4 → XP_006245957.1 caskin-1 isoform X1

UniProtKB/Swiss-Prot

Q8VHK2

Conserved Domains (11) summary

cd09497
Location:480 → 545

SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1

cd09498
Location:547 → 616

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

smart00454
Location:479 → 541

SAM; Sterile alpha motif

cd12062
Location:291 → 352

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

cd00204
Location:116 → 248

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:126 → 225

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:215 → 268

Ank_5; Ankyrin repeats (many copies)

pfam16600
Location:380 → 428

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1375 → 1437

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:884 → 955

Caskin-Pro-rich; Proline rich region of Caskin proteins

sd00045
Location:121 → 152

ANK; ANK repeat [structural motif]
XM_006245896.4 → XP_006245958.1 caskin-1 isoform X2

UniProtKB/Swiss-Prot

Q8VHK2

Conserved Domains (10) summary

cd09498
Location:483 → 545

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

smart00454
Location:487 → 542

SAM; Sterile alpha motif

cd12062
Location:291 → 352

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

cd00204
Location:116 → 248

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:126 → 225

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:215 → 268

Ank_5; Ankyrin repeats (many copies)

pfam16600
Location:380 → 428

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1304 → 1366

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:813 → 884

Caskin-Pro-rich; Proline rich region of Caskin proteins

sd00045
Location:121 → 152

ANK; ANK repeat [structural motif]
XM_006245897.4 → XP_006245959.1 caskin-1 isoform X3

UniProtKB/Swiss-Prot

Q8VHK2

UniProtKB/TrEMBL

D3ZE17, F1LS31

Related

ENSRNOP00000039956.5

Conserved Domains (11) summary

cd09498
Location:476 → 538

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

smart00454
Location:480 → 535

SAM; Sterile alpha motif

cd12062
Location:284 → 345

SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1

cd00204
Location:43 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:119 → 218

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:7 → 69

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:208 → 261

Ank_5; Ankyrin repeats (many copies)

pfam16600
Location:373 → 421

Caskin1-CID; Caskin1 CASK-interaction domain

pfam16632
Location:1297 → 1359

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:806 → 877

Caskin-Pro-rich; Proline rich region of Caskin proteins

sd00045
Location:114 → 145

ANK; ANK repeat [structural motif]
XM_039085091.1 → XP_038941019.1 caskin-1 isoform X4

Conserved Domains (5) summary

PTZ00449
Location:147 → 275

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd09498
Location:1 → 56

SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2

PRK12323
Location:664 → 853

PRK12323; DNA polymerase III subunit gamma/tau

pfam16632
Location:815 → 877

Caskin-tail; C-terminal region of Caskin

pfam16907
Location:324 → 395

Caskin-Pro-rich; Proline rich region of Caskin proteins