Msmo1 methylsterol monooxygenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Msmo1provided by RGD
Official Full Name: methylsterol monooxygenase 1provided by RGD
Primary source: RGD:620281
See related: Ensembl:ENSRNOG00000032297 AllianceGenome:RGD:620281
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sc4mol
Summary: Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 757.0), Brain (RPKM 458.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (29747113..29764360)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (24980680..24997927)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (26859441..26875880)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Among the identified sterol associated genes, we detected that methylsterol monooxygenase 1 (Msmo1) was more sensitively induced compared to Cyp51, a classical biomarker of this pathway. Therefore, we suggest that Msmo1 could be a better biomarker for screening the fungicidal value of azoles.
Title: A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture.

Submit: New GeneRIF Correction

General gene information

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Markers

RH126400 (e-PCR)
- UniSTS:163108

RH136901 (e-PCR)
- UniSTS:218990

RH128075 (e-PCR)
- UniSTS:211383

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-4 methylsterol oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methylsterol monooxygenase 1

Names: C-4 methylsterol oxidase; RANP-1; neuropep 1; neurorep 1; sterol-C4-methyl oxidase

NP_543162.1

EC 1.14.18.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.