Fgfr3 fibroblast growth factor receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgfr3provided by MGI
Official Full Name: fibroblast growth factor receptor 3provided by MGI
Primary source: MGI:MGI:95524
See related: Ensembl:ENSMUSG00000054252 AllianceGenome:MGI:95524
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3
Summary: This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
Expression: Broad expression in lung adult (RPKM 46.0), limb E14.5 (RPKM 23.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.83 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (33879068..33894412)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (33721724..33737068)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis.
Title: DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis.
Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice.
Title: Hypochondroplasia gain-of-function mutation in FGFR3 causes defective bone mineralization in mice.
Downregulated FGFR3 Expression Inhibits In Vitro Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells of Mice with TBXT Gene Mutation.
Title: Downregulated FGFR3 Expression Inhibits In Vitro Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells of Mice with TBXT Gene Mutation.
Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice.
Title: Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice.
FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model.
Title: FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model.
An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton.
Title: An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton.
Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway.
Title: Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway.
Loss of FGFR3 Accelerates Bone Marrow Suppression-Induced Hematopoietic Stem and Progenitor Cell Expansion by Activating FGFR1-ELK1-Cyclin D1 Signaling.
Title: Loss of FGFR3 Accelerates Bone Marrow Suppression-Induced Hematopoietic Stem and Progenitor Cell Expansion by Activating FGFR1-ELK1-Cyclin D1 Signaling.
FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair.
Title: FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair.
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.
Title: Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (27) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:143104

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:143105

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:507934

PMC156609P5 (e-PCR)
- UniSTS:271417

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:547905

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:166215

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:547921

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:480343

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:463449

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:463450

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:536433

M81342 (e-PCR)
- UniSTS:207770

NoName (e-PCR)
- UniSTS:548573

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:547829

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:547830

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:143102

Fgfr3 (e-PCR), detects polymorphism
- UniSTS:143103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within alveolar secondary septum development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis involved in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone trabecula morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cochlea development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lens morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mitotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroepithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of collagen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sodium phosphate	IDA Inferred from Direct Assay more info	PubMed
involved_in response to sodium phosphate	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within substantia nigra development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor receptor 3

Names: heparin-binding growth factor receptor

NP_001156687.1

EC 2.7.10.1

NP_001156688.1

EC 2.7.10.1

NP_001156689.1

EC 2.7.10.1

NP_001192199.1

EC 2.7.10.1

NP_001345965.1

EC 2.7.10.1

NP_001345966.1

EC 2.7.10.1

NP_032036.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163215.2 → NP_001156687.1 fibroblast growth factor receptor 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_001156687.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1, also known as IIIc), which includes the IIIc-type C-terminal half of the IgIII domain.

Source sequence(s)

AC162898

Consensus CDS

CCDS51465.1

UniProtKB/Swiss-Prot

Q61564, Q61851, Q63834

UniProtKB/TrEMBL

E9QLT8, Q3UPE1, Q7TSI8, Q99052

Related

ENSMUSP00000130856.3, ENSMUST00000169212.9

Conserved Domains (7) summary

cd05857
Location:155 → 239

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:262 → 351

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:453 → 786

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:51 → 110

IGc2; Immunoglobulin C-2 Type

smart00409
Location:52 → 108

IG; Immunoglobulin

smart00410
Location:254 → 350

IG_like; Immunoglobulin like

pfam07714
Location:466 → 742

Pkinase_Tyr; Protein tyrosine kinase
NM_001163216.2 → NP_001156688.1 fibroblast growth factor receptor 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_001156688.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC162898, AF024638

Consensus CDS

CCDS51466.1

UniProtKB/Swiss-Prot

Q61564, Q61851, Q63834

UniProtKB/TrEMBL

E9QAC2, Q3UPE1, Q61563, Q99052

Related

ENSMUSP00000143945.2, ENSMUST00000202138.4

Conserved Domains (7) summary

cd05857
Location:137 → 221

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:244 → 333

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:435 → 768

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:51 → 110

IGc2; Immunoglobulin C-2 Type

smart00409
Location:52 → 108

IG; Immunoglobulin

smart00410
Location:236 → 332

IG_like; Immunoglobulin like

pfam07714
Location:448 → 724

Pkinase_Tyr; Protein tyrosine kinase
NM_001163217.2 → NP_001156689.1 fibroblast growth factor receptor 3 isoform 3 precursor

See identical proteins and their annotated locations for NP_001156689.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks a coding exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3, also known as IIIb) is longer than isoform 1 and includes the IIIb-type C-terminal half of the IgIII domain. The combination of alternative exons and splice sites in the coding region is inferred based on human NM_001163213.1.

Source sequence(s)

AC162898

UniProtKB/Swiss-Prot

Q61564, Q61851, Q63834

UniProtKB/TrEMBL

E9QNJ9, Q3UPE1, Q99052

Related

ENSMUSP00000131845.3, ENSMUST00000171509.9

Conserved Domains (7) summary

cd04974
Location:262 → 350

Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)

cd05857
Location:155 → 239

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05100
Location:455 → 788

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:51 → 110

IGc2; Immunoglobulin C-2 Type

smart00409
Location:52 → 108

IG; Immunoglobulin

smart00410
Location:254 → 349

IG_like; Immunoglobulin like

pfam07714
Location:468 → 744

Pkinase_Tyr; Protein tyrosine kinase
NM_001205270.1 → NP_001192199.1 fibroblast growth factor receptor 3 isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.

Source sequence(s)

AC162898

Consensus CDS

CCDS57335.1

UniProtKB/TrEMBL

F6TK14, Q3UPE1

Related

ENSMUSP00000133064.4, ENSMUST00000164207.10

Conserved Domains (4) summary

cd05857
Location:155 → 239

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:262 → 351

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:454 → 787

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:51 → 110

IGc2; Immunoglobulin C-2 Type
NM_001359036.1 → NP_001345965.1 fibroblast growth factor receptor 3 isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice junction compared to isoform 1. The resulting isoform (4) has the same N- and C-termini and is 1 aa longer compared to isoform 1. Variants 5 and 6 both encode the same isoform (4).

Source sequence(s)

AC162898

Consensus CDS

CCDS57335.1

UniProtKB/TrEMBL

F6TK14, Q3UPE1

Conserved Domains (4) summary

cd05857
Location:155 → 239

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:262 → 351

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:454 → 787

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:51 → 110

IGc2; Immunoglobulin C-2 Type
NM_001359037.1 → NP_001345966.1 fibroblast growth factor receptor 3 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC162898

UniProtKB/TrEMBL

Q3TQL1

Conserved Domains (4) summary

cd05857
Location:3 → 87

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:110 → 199

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:301 → 634

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

pfam18123
Location:211 → 241

FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
NM_008010.5 → NP_032036.2 fibroblast growth factor receptor 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_032036.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1, also known as IIIc, which includes the IIIc-type C-terminal half of the IgIII domain. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC162898, BC053056, CD349897

Consensus CDS

CCDS51465.1

UniProtKB/Swiss-Prot

Q61564, Q61851, Q63834

UniProtKB/TrEMBL

E9QLT8, Q3UPE1, Q7TSI8, Q99052

Related

ENSMUSP00000070998.8, ENSMUST00000067150.14

Conserved Domains (7) summary

cd05857
Location:155 → 239

Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor

cd05858
Location:262 → 351

Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)

cd05100
Location:453 → 786

PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3

smart00408
Location:51 → 110

IGc2; Immunoglobulin C-2 Type

smart00409
Location:52 → 108

IG; Immunoglobulin

smart00410
Location:254 → 350

IG_like; Immunoglobulin like

pfam07714
Location:466 → 742

Pkinase_Tyr; Protein tyrosine kinase