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Fn1 fibronectin 1 [ Mus musculus (house mouse) ]

Gene ID: 14268, updated on 14-Jan-2025

Summary

Official Symbol
Fn1provided by MGI
Official Full Name
fibronectin 1provided by MGI
Primary source
MGI:MGI:95566
See related
Ensembl:ENSMUSG00000026193 AllianceGenome:MGI:95566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fn; Fn-1; E330027I09
Summary
Enables peptidase activator activity and receptor ligand activity. Involved in negative regulation of monocyte activation and response to muscle activity. Acts upstream of or within several processes, including calcium-independent cell-matrix adhesion; cell-substrate junction assembly; and positive regulation of axon extension. Located in apical plasma membrane and basement membrane. Is active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; egg cylinder; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in placenta adult (RPKM 211.5), liver E18 (RPKM 196.6) and 22 other tissues See more
Orthologs
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Genomic context

See Fn1 in Genome Data Viewer
Location:
1 C3; 1 36.05 cM
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (71624632..71692439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (71585473..71653280, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01239 Neighboring gene STARR-seq mESC enhancer starr_01240 Neighboring gene predicted gene 6947 Neighboring gene STARR-seq mESC enhancer starr_01242 Neighboring gene STARR-positive B cell enhancer ABC_E5770 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene STARR-seq mESC enhancer starr_01248 Neighboring gene STARR-seq mESC enhancer starr_01250 Neighboring gene apolipoprotein L 7d Neighboring gene PRP4 pre-mRNA processing factor 4 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC117493

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent PubMed 
enables heparin binding  
enables identical protein binding  
enables identical protein binding  
enables integrin binding  
enables integrin binding  
enables integrin binding  
enables mercury ion binding  
enables peptidase activator activity PubMed 
enables protease binding  
enables protease binding  
enables protein binding PubMed 
enables proteoglycan binding  
enables proteoglycan binding PubMed 
enables receptor ligand activity PubMed 
enables signaling receptor binding PubMed 
enables signaling receptor binding  
Items 1 - 25 of 51
Process Evidence Code Pubs
involved_in acute-phase response  
involved_in angiogenesis  
involved_in biological process involved in interaction with symbiont  
involved_in biological process involved in interaction with symbiont  
acts_upstream_of_or_within calcium-independent cell-matrix adhesion PubMed 
acts_upstream_of_or_within cell adhesion PubMed 
involved_in cell-matrix adhesion  
acts_upstream_of_or_within cell-matrix adhesion PubMed 
involved_in cell-matrix adhesion  
involved_in cell-substrate junction assembly  
acts_upstream_of_or_within cell-substrate junction assembly PubMed 
involved_in cellular response to interleukin-1  
involved_in cellular response to mercury ion  
involved_in endodermal cell differentiation  
involved_in endodermal cell differentiation  
involved_in extracellular matrix organization  
involved_in glial cell migration  
involved_in heart development  
involved_in integrin activation  
involved_in integrin activation  
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of collagen biosynthetic process  
involved_in negative regulation of monocyte activation PubMed 
involved_in negative regulation of monocyte activation  
involved_in negative regulation of transforming growth factor beta production  
involved_in negative regulation of transforming growth factor beta production  
involved_in nervous system development  
involved_in neural crest cell migration involved in autonomic nervous system development PubMed 
involved_in peptide cross-linking  
acts_upstream_of_or_within positive regulation of axon extension PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of chemotaxis  
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate  
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of ERK1 and ERK2 cascade  
involved_in regulation of cell shape  
involved_in regulation of protein phosphorylation  
involved_in response to muscle activity PubMed 
involved_in substrate adhesion-dependent cell spreading  
involved_in substrate adhesion-dependent cell spreading  
acts_upstream_of_or_within wound healing PubMed 
Items 1 - 25 of 51
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in basement membrane PubMed 
located_in basement membrane  
located_in collagen-containing extracellular matrix PubMed 
located_in collagen-containing extracellular matrix PubMed 
located_in collagen-containing extracellular matrix  
located_in endoplasmic reticulum-Golgi intermediate compartment  
located_in endoplasmic reticulum-Golgi intermediate compartment  
located_in extracellular exosome  
located_in extracellular exosome  
located_in extracellular matrix PubMed 
is_active_in extracellular matrix PubMed 
located_in extracellular matrix PubMed 
located_in extracellular space PubMed 
is_active_in extracellular space PubMed 
located_in extracellular space  
part_of fibrinogen complex  
part_of fibrinogen complex  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276408.1NP_001263337.1  fibronectin isoform b precursor

    See identical proteins and their annotated locations for NP_001263337.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147249, AK147683, CJ098561, CJ099024, CN534124
    Consensus CDS
    CCDS78612.1
    UniProtKB/TrEMBL
    A0A087WR50, Q3UGY5
    Related
    ENSMUSP00000140471.2, ENSMUST00000188894.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22932332
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  2. NM_001276409.1NP_001263338.1  fibronectin isoform c precursor

    See identical proteins and their annotated locations for NP_001263338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147315, CJ098561
    Consensus CDS
    CCDS78611.1
    UniProtKB/TrEMBL
    Q3UGY5, Q3UHL6
    Related
    ENSMUSP00000140975.2, ENSMUST00000187938.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22682307
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  3. NM_001276410.1NP_001263339.1  fibronectin isoform d precursor

    See identical proteins and their annotated locations for NP_001263339.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147315, AK171339, CJ098561, CK639246, CN532664, CN536551, CN692112
    Consensus CDS
    CCDS78609.1
    UniProtKB/TrEMBL
    A0A087WSN6, Q3TCF1
    Related
    ENSMUSP00000141123.2, ENSMUST00000186129.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22032242
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  4. NM_001276411.1NP_001263340.1  fibronectin isoform e precursor

    See identical proteins and their annotated locations for NP_001263340.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147663, BC138421, CJ098561
    Consensus CDS
    CCDS78608.1
    UniProtKB/TrEMBL
    B9EHT6, Q3TCF1
    Related
    ENSMUSP00000140816.2, ENSMUST00000190780.7
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21782217
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18131893
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:14501529
    fn3; Fibronectin type III domain
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
  5. NM_001276412.1NP_001263341.1  fibronectin isoform f precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147315, AK147639, CJ098561
    Consensus CDS
    CCDS78610.1
    UniProtKB/TrEMBL
    A0A087WS56, Q3UH17
    Related
    ENSMUSP00000140907.2, ENSMUST00000188674.7
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21732212
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19031983
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:14501529
    fn3; Fibronectin type III domain
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
  6. NM_001276413.1NP_001263342.1  fibronectin isoform g precursor

    See identical proteins and their annotated locations for NP_001263342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AC124821, AK147701, AK171339, CJ098561
    Consensus CDS
    CCDS78607.1
    UniProtKB/TrEMBL
    B7ZNJ1, Q3UH17
    Related
    ENSMUSP00000139702.2, ENSMUST00000189821.7
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:20832122
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15421622
    fn3; Fibronectin type III domain
  7. NM_010233.2NP_034363.1  fibronectin isoform a precursor

    See identical proteins and their annotated locations for NP_034363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC124821, AK133868, CF166960, CF727068, CJ098561, CK637170, CK638401, CN460535, CN534124, CN538894, CN694596
    Consensus CDS
    CCDS15031.1
    UniProtKB/Swiss-Prot
    G5E8B8, P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4
    UniProtKB/TrEMBL
    Q3UGY5
    Related
    ENSMUSP00000054499.7, ENSMUST00000055226.13
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23842423
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19942074
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:15411620
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    71624632..71692439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315837.2XP_017171326.1  fibronectin isoform X5

    UniProtKB/TrEMBL
    Q3UH17
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21742213
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  2. XM_030248098.1XP_030103958.1  fibronectin isoform X3

    UniProtKB/TrEMBL
    Q3TCF1
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22692308
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  3. XM_006495699.4XP_006495762.1  fibronectin isoform X2

    See identical proteins and their annotated locations for XP_006495762.1

    UniProtKB/TrEMBL
    Q3TCF1
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  4. XM_006495700.4XP_006495763.1  fibronectin isoform X4

    UniProtKB/TrEMBL
    Q3UH17
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
  5. XM_006495697.4XP_006495760.1  fibronectin isoform X1

    UniProtKB/TrEMBL
    Q3UGY5
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:187231
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23592398
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:232271
    fn1; Fibronectin type I domain
    pfam00041
    Location:16331713
    fn3; Fibronectin type III domain
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