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Fut2 fucosyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 14344, updated on 7-May-2024

Summary

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Official Symbol
Fut2provided by MGI
Official Full Name
fucosyltransferase 2provided by MGI
Primary source
MGI:MGI:109374
See related
Ensembl:ENSMUSG00000055978 AllianceGenome:MGI:109374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MFUT-II
Summary
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Biased expression in colon adult (RPKM 53.5), stomach adult (RPKM 21.9) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Fut2 in Genome Data Viewer
Location:
7 B3; 7 29.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45298015..45315818, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45648591..45666394, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ras interacting protein 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense. Kamioka M, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35027453, Free PMC Article
  2. Deficiency of Intestinal α1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice. Zhou R, et al. Alcohol Clin Exp Res, 2020 Sep. PMID 32628772, Free PMC Article
  3. Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways. Saku A, et al. Allergy, 2020 May. PMID 31709563
  4. Multigenerational Influences of the Fut2 Gene on the Dynamics of the Gut Microbiota in Mice. Rausch P, et al. Front Microbiol, 2017. PMID 28642740, Free PMC Article
  5. Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice. Maroni L, et al. Hepatology, 2017 Aug. PMID 28056490

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
    Title: FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
  2. FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
    Title: FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
  3. Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
    Title: Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
  4. Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense.
    Title: Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense.
  5. Deficiency of Intestinal alpha1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice.
    Title: Deficiency of Intestinal α1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice.
  6. Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways.
    Title: Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways.
  7. Our data suggest that Fut2 plays a key role in immune responses in the lung and could be a novel therapeutic target of asthma.
    Title: Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation.
  8. Results indicate that the fucosyltransferase 2 (FUT2) determines the O-glycosylation pattern of mucin-5AC (Muc5ac).
    Title: Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding.
  9. Fut2 gene expression is responsible for disease progression in mice with primary sclerosing cholangitis.
    Title: Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.
  10. We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis.
    Title: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-(1,2)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-(1,2)-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-(1,2)-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactoside 2-alpha-L-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactoside 2-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactoside 2-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables galactoside 2-alpha-L-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fucosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fucosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactoside alpha-(1,2)-fucosyltransferase 2
Names
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase
alpha(1,2)FT 2
galactoside 2-alpha-L-fucosyltransferase 2
secretory blood group protein 2
type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
NP_001258922.1
NP_061364.2
XP_011249097.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271993.1 → NP_001258922.1  galactoside alpha-(1,2)-fucosyltransferase 2

    See identical proteins and their annotated locations for NP_001258922.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033520, AK033586, BC145831, BQ032725, BY142283
    Consensus CDS
    CCDS21258.1
    UniProtKB/Swiss-Prot
    O70504, Q9JL27
    UniProtKB/TrEMBL
    A6H6C9, Q91VF0
    Conserved Domains (1) summary
    pfam01531
    Location:59 → 337
    Glyco_transf_11; Glycosyl transferase family 11

  2. NM_018876.4 → NP_061364.2  galactoside alpha-(1,2)-fucosyltransferase 2

    See identical proteins and their annotated locations for NP_061364.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033520, AK033586, BC145831, BQ032725
    Consensus CDS
    CCDS21258.1
    UniProtKB/Swiss-Prot
    O70504, Q9JL27
    UniProtKB/TrEMBL
    A6H6C9, Q91VF0
    Related
    ENSMUSP00000063719.5, ENSMUST00000069800.6
    Conserved Domains (1) summary
    pfam01531
    Location:59 → 337
    Glyco_transf_11; Glycosyl transferase family 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45298015..45315818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250795.3 → XP_011249097.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011249097.1

    UniProtKB/Swiss-Prot
    O70504, Q9JL27
    UniProtKB/TrEMBL
    A6H6C9, Q91VF0
    Conserved Domains (1) summary
    pfam01531
    Location:59 → 337
    Glyco_transf_11; Glycosyl transferase family 11
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL27.1 GenPept UniProtKB/Swiss-Prot:Q9JL27

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