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Gad2 glutamic acid decarboxylase 2 [ Mus musculus (house mouse) ]

Gene ID: 14417, updated on 4-Jan-2025

Summary

Official Symbol
Gad2provided by MGI
Official Full Name
glutamic acid decarboxylase 2provided by MGI
Primary source
MGI:MGI:95634
See related
Ensembl:ENSMUSG00000026787 AllianceGenome:MGI:95634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAD65; Gad-2; GAD(65); 6330404F12Rik
Summary
Predicted to enable glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Predicted to be involved in gamma-aminobutyrate shunt and gamma-aminobutyric acid biosynthetic process. Located in axon; cytoplasm; and synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Used to study epilepsy and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; diabetes mellitus (multiple); drug psychosis; and heroin dependence. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in frontal lobe adult (RPKM 14.3), whole brain E14.5 (RPKM 8.4) and 5 other tissues See more
Orthologs
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Genomic context

See Gad2 in Genome Data Viewer
Location:
2 A3; 2 15.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22512262..22583889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22621015..22693877)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_03908 Neighboring gene STARR-seq mESC enhancer starr_03909 Neighboring gene myosin IIIA Neighboring gene STARR-seq mESC enhancer starr_03910 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene microRNA 3967 Neighboring gene STARR-seq mESC enhancer starr_03915 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4417 Neighboring gene STARR-seq mESC enhancer starr_03917 Neighboring gene amyloid beta precursor protein binding family B member 1 interacting protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:22661206-22661359 Neighboring gene STARR-positive B cell enhancer ABC_E7796 Neighboring gene STARR-seq mESC enhancer starr_03918 Neighboring gene STARR-seq mESC enhancer starr_03919 Neighboring gene predicted gene, 52503

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (15)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutamate binding  
enables glutamate binding  
enables glutamate decarboxylase activity  
enables glutamate decarboxylase activity  
enables glutamate decarboxylase activity  
enables protein-containing complex binding  
enables protein-containing complex binding  
enables pyridoxal phosphate binding  
enables pyridoxal phosphate binding  
Process Evidence Code Pubs
involved_in cellular response to brain-derived neurotrophic factor stimulus  
involved_in cellular response to hypoxia  
involved_in gamma-aminobutyrate shunt  
involved_in gamma-aminobutyrate shunt  
involved_in gamma-aminobutyrate shunt  
involved_in gamma-aminobutyric acid biosynthetic process  
involved_in gamma-aminobutyric acid biosynthetic process  
involved_in gamma-aminobutyric acid biosynthetic process  
involved_in response to caloric restriction  
involved_in response to cocaine  
involved_in response to dexamethasone  
involved_in response to progesterone  
involved_in response to xenobiotic stimulus  
Component Evidence Code Pubs
located_in GABA-ergic synapse  
is_active_in GABA-ergic synapse  
located_in Golgi membrane  
located_in axon PubMed 
located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in inhibitory synapse PubMed 
located_in neuronal cell body  
located_in neuronal cell body  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
is_active_in presynapse  
located_in presynapse  
located_in presynaptic membrane  
located_in synapse PubMed 
located_in synapse  
located_in synaptic vesicle membrane  
located_in synaptic vesicle membrane  

General protein information

Preferred Names
glutamate decarboxylase 2
Names
65 kDa glutamic acid decarboxylase
GAD-65
NP_032104.2
XP_011237325.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008078.2NP_032104.2  glutamate decarboxylase 2

    See identical proteins and their annotated locations for NP_032104.2

    Status: VALIDATED

    Source sequence(s)
    AL928693, BC018380, BQ571205
    Consensus CDS
    CCDS15724.1
    UniProtKB/Swiss-Prot
    O35519, P48320
    UniProtKB/TrEMBL
    Q548L4
    Related
    ENSMUSP00000028123.4, ENSMUST00000028123.4
    Conserved Domains (1) summary
    pfam00282
    Location:138509
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    22512262..22583889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239023.4XP_011237325.1  glutamate decarboxylase 2 isoform X1

    Conserved Domains (1) summary
    cl18945
    Location:138307
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
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