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Ggh gamma-glutamyl hydrolase [ Mus musculus (house mouse) ]

Gene ID: 14590, updated on 30-Apr-2024

Summary

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Official Symbol
Gghprovided by MGI
Official Full Name
gamma-glutamyl hydrolaseprovided by MGI
Primary source
MGI:MGI:1329035
See related
Ensembl:ENSMUSG00000073987 AllianceGenome:MGI:1329035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gamma-GH
Summary
Predicted to enable gamma-glutamyl-peptidase activity. Predicted to be involved in several processes, including poly-gamma-glutamate metabolic process; response to ethanol; and tetrahydrofolylpolyglutamate metabolic process. Located in extracellular space. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.2), colon adult (RPKM 5.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 7.79 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (20041963..20066111)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (20041997..20066111)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09707 Neighboring gene RIKEN cDNA 4930598A11 gene Neighboring gene tocopherol (alpha) transfer protein Neighboring gene small cell adhesion glycoprotein pseudogene Neighboring gene Na+/K+ transporting ATPase interacting 3 Neighboring gene STARR-seq mESC enhancer starr_09708 Neighboring gene STARR-positive B cell enhancer mm9_chr4:20118894-20119195 Neighboring gene predicted gene, 52761

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression. Masumoto N, et al. Gene, 2002 May 29. PMID 12095690
  2. Additional organizational features of the murine gamma-glutamyl hydrolase gene. Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter. Masumoto N, et al. Gene, 2001 May 2. PMID 11368914
  3. Organization and structure of the mouse gamma-glutamyl hydrolase gene and the functional identification of its promoter. Esaki T, et al. Gene, 1999 Jun 24. PMID 10393243
  4. Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences. Esaki T, et al. Gene, 1998 Sep 28. PMID 9756990
  5. High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis. Uematsu R, et al. Mol Cell Proteomics, 2005 Dec. PMID 16170054

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-glutamyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-glutamyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables omega peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
  
involved_in tetrahydrofolylpolyglutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome TAS
Traceable Author Statement
more info
 PubMed 
is_active_in vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-glutamyl hydrolase
Names
FGPH
GH
conjugase
folylpolyglutamate hydrolase
gamma-Glu-x carboxypeptidase
NP_034411.2
XP_006537682.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010281.2 → NP_034411.2  gamma-glutamyl hydrolase precursor

    See identical proteins and their annotated locations for NP_034411.2

    Status: VALIDATED

    Source sequence(s)
    AI840300, AI846732, AL732527, BB610405, BE859353, CO044650
    Consensus CDS
    CCDS51126.1
    UniProtKB/Swiss-Prot
    B1AWC1, Q9Z0L7, Q9Z0L8
    UniProtKB/TrEMBL
    B9EKG3
    Related
    ENSMUSP00000095843.4, ENSMUST00000098242.4
    Conserved Domains (2) summary
    pfam07722
    Location:34 → 245
    Peptidase_C26; Peptidase C26
    cl00020
    Location:36 → 305
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    20041963..20066111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537619.4 → XP_006537682.1  gamma-glutamyl hydrolase isoform X1

    Conserved Domains (1) summary
    cl00020
    Location:36 → 231
    GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0L8.2 GenPept UniProtKB/Swiss-Prot:Q9Z0L8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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