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Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) [ Mus musculus (house mouse) ]

Gene ID: 14799, updated on 7-Jan-2025

Summary

Official Symbol
Gria1provided by MGI
Official Full Name
glutamate receptor, ionotropic, AMPA1 (alpha 1)provided by MGI
Primary source
MGI:MGI:95808
See related
Ensembl:ENSMUSG00000020524 AllianceGenome:MGI:95808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glr1; Glr-1; GluA1; GluRA; Glur1; HIPA1; GluR-A; Glur-1; gluR-K1; 2900051M01Rik
Summary
Enables AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in long-term memory; receptor internalization; and synapse assembly. Acts upstream of or within cellular response to ammonium ion; chemical synaptic transmission; and long-term synaptic depression. Located in several cellular components, including dendrite membrane; neuron spine; and perisynaptic space. Part of AMPA glutamate receptor complex. Is active in excitatory synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study schizoaffective disorder. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in frontal lobe adult (RPKM 40.2), cerebellum adult (RPKM 32.5) and 4 other tissues See more
Orthologs
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Genomic context

See Gria1 in Genome Data Viewer
Location:
11 B1.3; 11 34.51 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (56902342..57221070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57011571..57330244)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46261 Neighboring gene STARR-seq mESC enhancer starr_29563 Neighboring gene STARR-seq mESC enhancer starr_29564 Neighboring gene predicted gene, 39826 Neighboring gene STARR-seq mESC enhancer starr_29566 Neighboring gene STARR-seq mESC enhancer starr_29569 Neighboring gene STARR-seq mESC enhancer starr_29570 Neighboring gene STARR-positive B cell enhancer mm9_chr11:56989490-56989791 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene predicted gene, 53706

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 48
Function Evidence Code Pubs
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity PubMed 
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity  
enables G-protein alpha-subunit binding  
enables G-protein alpha-subunit binding  
enables G-protein beta-subunit binding  
enables G-protein beta-subunit binding  
enables PDZ domain binding  
enables PDZ domain binding  
enables adenylate cyclase binding  
enables adenylate cyclase binding  
enables amyloid-beta binding  
enables amyloid-beta binding  
enables beta-2 adrenergic receptor binding  
enables beta-2 adrenergic receptor binding  
enables glutamate receptor binding  
enables glutamate receptor binding  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated receptor activity PubMed 
enables glutamate-gated receptor activity  
enables identical protein binding  
enables identical protein binding  
enables immunoglobulin binding  
enables immunoglobulin binding  
enables ionotropic glutamate receptor binding  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables myosin V binding  
enables myosin V binding  
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
enables peptide hormone receptor binding  
enables peptide hormone receptor binding  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein kinase A binding  
enables protein kinase A binding  
enables protein kinase binding  
enables protein kinase binding  
enables scaffold protein binding  
enables scaffold protein binding  
enables small GTPase binding  
enables small GTPase binding  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
Items 1 - 25 of 48
Items 1 - 25 of 58
Process Evidence Code Pubs
involved_in behavioral response to pain  
involved_in calcium-mediated signaling  
involved_in cellular response to L-glutamate  
involved_in cellular response to amine stimulus  
acts_upstream_of_or_within cellular response to ammonium ion PubMed 
involved_in cellular response to brain-derived neurotrophic factor stimulus  
involved_in cellular response to brain-derived neurotrophic factor stimulus  
involved_in cellular response to dsRNA  
involved_in cellular response to peptide hormone stimulus  
involved_in cerebral cortex development  
acts_upstream_of_or_within chemical synaptic transmission PubMed 
involved_in conditioned place preference  
involved_in conditioned place preference  
involved_in ionotropic glutamate receptor signaling pathway  
involved_in long-term memory PubMed 
involved_in long-term memory  
acts_upstream_of_or_within long-term synaptic depression PubMed 
involved_in long-term synaptic potentiation  
involved_in modulation of chemical synaptic transmission  
involved_in modulation of chemical synaptic transmission  
involved_in monoatomic ion transmembrane transport  
involved_in neuronal action potential  
involved_in neuronal action potential  
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of locomotion involved in locomotory behavior  
involved_in positive regulation of locomotion involved in locomotory behavior  
involved_in positive regulation of membrane potential  
involved_in positive regulation of membrane potential  
involved_in positive regulation of synaptic transmission  
involved_in receptor internalization PubMed 
involved_in receptor internalization  
involved_in regulation of monoatomic ion transmembrane transport  
involved_in regulation of monoatomic ion transmembrane transport  
involved_in regulation of postsynaptic membrane potential  
involved_in regulation of presynaptic membrane potential  
involved_in regulation of receptor recycling  
involved_in regulation of receptor recycling  
involved_in regulation of synaptic plasticity  
involved_in response to arsenic-containing substance  
involved_in response to cocaine  
involved_in response to electrical stimulus  
involved_in response to estradiol  
involved_in response to ethanol  
involved_in response to fungicide  
involved_in response to lithium ion  
involved_in response to morphine  
involved_in response to morphine  
involved_in response to nutrient levels  
involved_in response to psychosocial stress  
involved_in response to sucrose  
involved_in response to toxic substance  
involved_in response to xenobiotic stimulus  
involved_in spinal cord development  
involved_in synapse assembly PubMed 
involved_in synaptic transmission, glutamatergic  
Items 1 - 25 of 58
Items 1 - 20 of 85
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex  
part_of AMPA glutamate receptor complex PubMed 
part_of AMPA glutamate receptor complex  
located_in asymmetric synapse  
located_in axonal spine PubMed 
located_in cell body PubMed 
is_active_in cell surface PubMed 
located_in cell surface PubMed 
located_in cell surface PubMed 
located_in cell surface  
located_in cell-cell junction  
located_in cell-cell junction  
located_in cytosol  
located_in cytosol  
located_in dendrite PubMed 
located_in dendrite  
located_in dendrite membrane PubMed 
located_in dendrite membrane PubMed 
located_in dendrite membrane  
located_in dendritic shaft  
located_in dendritic shaft  
is_active_in dendritic spine  
located_in dendritic spine PubMed 
located_in dendritic spine  
is_active_in dendritic spine membrane PubMed 
located_in dendritic spine membrane  
located_in early endosome  
located_in early endosome membrane  
located_in early endosome membrane  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
is_active_in excitatory synapse PubMed 
located_in excitatory synapse  
located_in external side of plasma membrane  
is_active_in glutamatergic synapse PubMed 
located_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
part_of ionotropic glutamate receptor complex PubMed 
located_in membrane PubMed 
located_in neuromuscular junction  
located_in neuromuscular junction  
located_in neuron projection PubMed 
located_in neuron spine PubMed 
located_in neuron spine  
is_active_in neuronal cell body PubMed 
located_in neuronal cell body PubMed 
located_in neuronal cell body  
located_in neuronal cell body membrane  
located_in neuronal cell body membrane  
located_in perisynaptic space PubMed 
is_active_in plasma membrane  
is_active_in plasma membrane PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in postsynapse PubMed 
located_in postsynaptic density PubMed 
located_in postsynaptic density  
is_active_in postsynaptic density membrane  
is_active_in postsynaptic density membrane PubMed 
located_in postsynaptic density membrane PubMed 
is_active_in postsynaptic density membrane  
located_in postsynaptic density, intracellular component  
located_in postsynaptic density, intracellular component  
located_in postsynaptic membrane PubMed 
is_active_in postsynaptic membrane  
located_in postsynaptic membrane  
located_in presynapse PubMed 
located_in presynaptic active zone membrane  
is_active_in presynaptic active zone membrane  
is_active_in presynaptic membrane  
part_of protein-containing complex  
located_in proximal dendrite  
located_in proximal dendrite  
located_in recycling endosome  
located_in recycling endosome membrane  
located_in recycling endosome membrane  
located_in somatodendritic compartment PubMed 
located_in synapse PubMed 
located_in synapse PubMed 
located_in synaptic membrane PubMed 
located_in synaptic membrane  
located_in synaptic vesicle PubMed 
located_in synaptic vesicle membrane PubMed 
Items 1 - 20 of 85

General protein information

Preferred Names
glutamate receptor 1
Names
AMPA-selective glutamate receptor 1
glutamate receptor A
glutamate receptor ionotropic, AMPA 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113325.2NP_001106796.1  glutamate receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001106796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame exon, compared to variant 2, resulting in a protein (isoform 1) with a distinct internal segment compared to isoform 2.
    Source sequence(s)
    AK049958, AL663055, BC056397
    Consensus CDS
    CCDS48800.1
    UniProtKB/Swiss-Prot
    P23818
    UniProtKB/TrEMBL
    C9K0Y3
    Related
    ENSMUSP00000044494.10, ENSMUST00000036315.16
    Conserved Domains (2) summary
    cd13729
    Location:406787
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06390
    Location:26392
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
  2. NM_001252403.1NP_001239332.1  glutamate receptor 1 isoform 3

    See identical proteins and their annotated locations for NP_001239332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK135107, AL672177, BC056397
    Consensus CDS
    CCDS56770.1
    UniProtKB/TrEMBL
    C9K0Y3, F6YNQ1
    Related
    ENSMUSP00000117746.3, ENSMUST00000151045.3
    Conserved Domains (2) summary
    cd13729
    Location:337718
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1323
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  3. NM_008165.4NP_032191.2  glutamate receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_032191.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon, compared to variant 1, resulting in a protein (isoform 2) with a distinct internal segment compared to isoform 1.
    Source sequence(s)
    AL663055, BC056397
    Consensus CDS
    CCDS36159.1
    UniProtKB/TrEMBL
    Q6P9M2, Q7TNB5
    Related
    ENSMUSP00000091731.5, ENSMUST00000094179.11
    Conserved Domains (4) summary
    cd06390
    Location:26389
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    cd13729
    Location:406787
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:538817
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:37372
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    56902342..57221070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314275.3XP_017169764.1  glutamate receptor 1 isoform X2

    UniProtKB/TrEMBL
    Q6P9M2
    Conserved Domains (2) summary
    cd13729
    Location:337718
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1323
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  2. XM_006532234.5XP_006532297.1  glutamate receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006532297.1

    UniProtKB/TrEMBL
    C9K0Y3, F6YNQ1
    Conserved Domains (2) summary
    cd13729
    Location:337718
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1323
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RNA

  1. XR_388348.3 RNA Sequence

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