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Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) [ Mus musculus (house mouse) ]

Gene ID: 14811, updated on 28-Jan-2025

Summary

Official Symbol
Grin2aprovided by MGI
Official Full Name
glutamate receptor, ionotropic, NMDA2A (epsilon 1)provided by MGI
Primary source
MGI:MGI:95820
See related
Ensembl:ENSMUSG00000059003 AllianceGenome:MGI:95820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NR2A; GluN2A; NMDAR2A; GluRepsilon1
Summary
Enables NMDA glutamate receptor activity and calcium channel activity. Involved in glutamate receptor signaling pathway and regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including cell surface; synaptic membrane; and synaptic vesicle. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cortex adult (RPKM 2.7), frontal lobe adult (RPKM 1.8) and 3 other tissues See more
Orthologs
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Genomic context

See Grin2a in Genome Data Viewer
Location:
16 A1; 16 5.28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (9385765..9813744, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (9567901..9996083, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40052 Neighboring gene STARR-seq mESC enhancer starr_40054 Neighboring gene STARR-seq mESC enhancer starr_40055 Neighboring gene predicted gene, 53934 Neighboring gene STARR-seq mESC enhancer starr_40058 Neighboring gene predicted gene, 41418 Neighboring gene STARR-seq mESC enhancer starr_40060 Neighboring gene STARR-seq mESC enhancer starr_40064 Neighboring gene STARR-seq mESC enhancer starr_40065 Neighboring gene STARR-seq mESC enhancer starr_40066 Neighboring gene STARR-seq mESC enhancer starr_40067 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40068 Neighboring gene STARR-seq mESC enhancer starr_40069 Neighboring gene predicted gene, 30668 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 32
Function Evidence Code Pubs
enables ATPase binding  
contributes_to NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity  
enables NMDA glutamate receptor activity  
contributes_to calcium channel activity PubMed 
enables calcium channel activity PubMed 
enables calcium-dependent protein binding  
enables cell adhesion molecule binding  
contributes_to extracellularly glutamate-gated ion channel activity  
enables glutamate binding  
enables glutamate receptor activity  
enables glutamate receptor binding  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated calcium ion channel activity  
contributes_to glutamate-gated receptor activity  
enables glutamate-gated receptor activity  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables monoatomic cation channel activity PubMed 
contributes_to monoatomic cation channel activity  
enables protein binding PubMed 
enables protein kinase binding  
enables protein tyrosine kinase binding  
enables protein-containing complex binding  
enables scaffold protein binding  
enables signaling receptor binding  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables voltage-gated monoatomic cation channel activity  
enables zinc ion binding  
enables zinc ion binding  
Items 1 - 25 of 32
Items 1 - 25 of 75
Process Evidence Code Pubs
involved_in action potential  
involved_in calcium ion transmembrane import into cytosol  
involved_in calcium ion transmembrane import into cytosol  
acts_upstream_of_or_within calcium ion transport PubMed 
acts_upstream_of_or_within calcium ion transport PubMed 
involved_in calcium-mediated signaling  
involved_in cellular response to amino acid stimulus  
involved_in cellular response to zinc ion  
acts_upstream_of_or_within chemical synaptic transmission PubMed 
involved_in chemical synaptic transmission  
involved_in dendritic spine organization  
NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain PubMed 
acts_upstream_of_or_within directional locomotion PubMed 
acts_upstream_of_or_within dopamine metabolic process PubMed 
involved_in excitatory postsynaptic potential  
acts_upstream_of_or_within excitatory postsynaptic potential PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential PubMed 
involved_in excitatory postsynaptic potential  
involved_in glutamate receptor signaling pathway PubMed 
involved_in ionotropic glutamate receptor signaling pathway  
involved_in ionotropic glutamate receptor signaling pathway  
acts_upstream_of_or_within learning PubMed 
acts_upstream_of_or_within learning or memory PubMed 
acts_upstream_of_or_within locomotion PubMed 
involved_in locomotory behavior PubMed 
involved_in long-term synaptic potentiation  
acts_upstream_of_or_within long-term synaptic potentiation PubMed 
acts_upstream_of_or_within long-term synaptic potentiation PubMed 
acts_upstream_of_or_within memory PubMed 
involved_in memory  
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of excitatory postsynaptic potential  
involved_in monoatomic cation transmembrane transport  
involved_in monoatomic cation transmembrane transport  
acts_upstream_of_or_within negative regulation of protein catabolic process PubMed 
acts_upstream_of_or_within neurogenesis PubMed 
involved_in neurotransmitter receptor transport, plasma membrane to endosome  
acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of inhibitory postsynaptic potential  
involved_in positive regulation of protein targeting to membrane  
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in positive regulation of synaptic transmission, glutamatergic  
acts_upstream_of protein catabolic process PubMed 
acts_upstream_of_or_within protein localization to postsynaptic membrane PubMed 
acts_upstream_of_or_within protein localization to postsynaptic membrane PubMed 
involved_in receptor recycling  
involved_in regulation of ARF protein signal transduction  
involved_in regulation of long-term neuronal synaptic plasticity  
acts_upstream_of_or_within regulation of membrane potential PubMed 
involved_in regulation of membrane potential  
involved_in regulation of monoatomic cation transmembrane transport  
involved_in regulation of monoatomic cation transmembrane transport  
involved_in regulation of neuronal synaptic plasticity PubMed 
acts_upstream_of_or_within regulation of postsynaptic membrane potential PubMed 
involved_in regulation of synaptic plasticity PubMed 
involved_in regulation of synaptic plasticity PubMed 
acts_upstream_of_or_within response to amphetamine PubMed 
acts_upstream_of_or_within response to ethanol PubMed 
involved_in response to ethanol  
involved_in response to lithium ion  
acts_upstream_of_or_within response to wounding PubMed 
acts_upstream_of_or_within response to wounding PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
involved_in rhythmic process  
acts_upstream_of_or_within sensory perception of pain PubMed 
acts_upstream_of_or_within serotonin metabolic process PubMed 
acts_upstream_of_or_within sleep PubMed 
involved_in sodium ion transmembrane transport  
acts_upstream_of_or_within startle response PubMed 
NOT acts_upstream_of_or_within startle response PubMed 
acts_upstream_of_or_within startle response PubMed 
involved_in synaptic transmission, glutamatergic  
acts_upstream_of_or_within visual learning PubMed 
Items 1 - 25 of 75
Items 1 - 20 of 40
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex PubMed 
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex  
located_in cell surface PubMed 
located_in cell surface PubMed 
located_in cell surface  
located_in cytoplasm  
located_in cytoplasmic vesicle membrane  
located_in dendrite membrane  
located_in dendritic spine PubMed 
located_in endoplasmic reticulum PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in membrane PubMed 
located_in neuron projection PubMed 
located_in neuron projection PubMed 
located_in neuron projection  
is_active_in parallel fiber to Purkinje cell synapse  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynapse PubMed 
is_active_in postsynaptic density PubMed 
located_in postsynaptic density PubMed 
located_in postsynaptic density  
is_active_in postsynaptic density membrane  
is_active_in postsynaptic density membrane PubMed 
located_in postsynaptic density, intracellular component  
located_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
located_in postsynaptic membrane PubMed 
located_in presynaptic membrane PubMed 
is_active_in presynaptic membrane  
located_in presynaptic membrane  
located_in synapse PubMed 
located_in synaptic membrane PubMed 
located_in synaptic vesicle PubMed 
located_in terminal bouton  
Items 1 - 20 of 40

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 2A
Names
N-methyl D-aspartate receptor subtype 2A
glutamate [NMDA] receptor subunit epsilon-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008170.4NP_032196.2  glutamate receptor ionotropic, NMDA 2A precursor

    See identical proteins and their annotated locations for NP_032196.2

    Status: VALIDATED

    Source sequence(s)
    AC121974, AC126022, AC154190, AC164163
    Consensus CDS
    CCDS27943.1
    UniProtKB/Swiss-Prot
    P35436
    Related
    ENSMUSP00000142900.2, ENSMUST00000199708.5
    Conserved Domains (5) summary
    cd06378
    Location:32392
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    COG0834
    Location:458541
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13718
    Location:403802
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:556828
    Lig_chan; Ligand-gated ion channel
    pfam10565
    Location:8391464
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    9385765..9813744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521795.5XP_006521858.1  glutamate receptor ionotropic, NMDA 2A isoform X1

    Conserved Domains (3) summary
    pfam00060
    Location:556717
    Lig_chan; Ligand-gated ion channel
    cd06378
    Location:32387
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cl21456
    Location:403723
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
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