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Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) [ Mus musculus (house mouse) ]

Gene ID: 14812, updated on 5-Jan-2025

Summary

Official Symbol
Grin2bprovided by MGI
Official Full Name
glutamate receptor, ionotropic, NMDA2B (epsilon 2)provided by MGI
Primary source
MGI:MGI:95821
See related
Ensembl:ENSMUSG00000030209 AllianceGenome:MGI:95821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NR2B; GluN2B; Nmdar2b; GluRepsilon2
Summary
Enables NMDA glutamate receptor activity and calcium channel activity. Involved in negative regulation of dendritic spine maintenance and regulation of synaptic plasticity. Acts upstream of or within several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cytoplasmic vesicle; lysosome; and synaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cortex adult (RPKM 5.7), frontal lobe adult (RPKM 5.7) and 5 other tissues See more
Orthologs
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Genomic context

See Grin2b in Genome Data Viewer
Location:
6 G1; 6 66.38 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135690219..136150658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135713221..136173615, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930425L21 gene Neighboring gene STARR-seq mESC enhancer starr_17574 Neighboring gene predicted gene, 38911 Neighboring gene STARR-seq mESC enhancer starr_17582 Neighboring gene predicted gene 14329 Neighboring gene predicted gene 14330 Neighboring gene STARR-seq mESC enhancer starr_17584 Neighboring gene predicted gene, 26653 Neighboring gene STARR-seq mESC enhancer starr_17586 Neighboring gene zinc finger protein 707 pseudogene Neighboring gene predicted gene, 26105

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 33
Function Evidence Code Pubs
enables D2 dopamine receptor binding  
enables NMDA glutamate receptor activity  
enables NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity  
enables NMDA glutamate receptor activity  
enables beta-catenin binding  
enables calcium channel activity PubMed 
enables cell adhesion molecule binding  
enables extracellularly glutamate-gated ion channel activity  
enables glutamate binding  
enables glutamate binding  
enables glutamate receptor binding  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated receptor activity  
enables glycine binding  
enables heterocyclic compound binding  
enables interleukin-1 receptor binding  
enables ionotropic glutamate receptor binding  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables monoatomic cation channel activity PubMed 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
enables protein binding PubMed 
enables protein tyrosine kinase binding  
enables protein-containing complex binding  
enables scaffold protein binding  
enables signaling receptor binding  
enables small molecule binding  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables zinc ion binding  
enables zinc ion binding  
Items 1 - 25 of 33
Items 1 - 25 of 65
Process Evidence Code Pubs
involved_in NMDA selective glutamate receptor signaling pathway  
involved_in action potential  
involved_in associative learning  
acts_upstream_of_or_within behavioral fear response PubMed 
involved_in behavioral fear response  
acts_upstream_of_or_within behavioral response to pain PubMed 
involved_in calcium ion transmembrane import into cytosol  
involved_in calcium ion transmembrane import into cytosol  
acts_upstream_of_or_within calcium ion transport PubMed 
involved_in calcium-mediated signaling  
acts_upstream_of_or_within chemical synaptic transmission PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain PubMed 
acts_upstream_of_or_within embryo development PubMed 
involved_in excitatory postsynaptic potential  
acts_upstream_of_or_within excitatory postsynaptic potential PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential PubMed 
acts_upstream_of_or_within fear response PubMed 
acts_upstream_of_or_within in utero embryonic development PubMed 
involved_in intracellular calcium ion homeostasis  
involved_in ionotropic glutamate receptor signaling pathway  
involved_in ionotropic glutamate receptor signaling pathway  
acts_upstream_of_or_within learning PubMed 
acts_upstream_of_or_within learning PubMed 
involved_in learning or memory  
involved_in learning or memory PubMed 
involved_in long-term synaptic potentiation  
acts_upstream_of_or_within long-term synaptic potentiation PubMed 
acts_upstream_of_or_within long-term synaptic potentiation PubMed 
acts_upstream_of_or_within memory PubMed 
acts_upstream_of_or_within memory PubMed 
involved_in memory  
involved_in monoatomic cation transmembrane transport  
acts_upstream_of_or_within monoatomic cation transport PubMed 
involved_in negative regulation of dendritic spine maintenance PubMed 
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of glutamate secretion  
involved_in positive regulation of inhibitory postsynaptic potential  
involved_in positive regulation of synaptic transmission  
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in protein heterotetramerization  
involved_in protein heterotetramerization  
involved_in receptor clustering  
involved_in regulation of ARF protein signal transduction  
involved_in regulation of MAPK cascade  
acts_upstream_of_or_within regulation of cAMP/PKA signal transduction PubMed 
involved_in regulation of long-term neuronal synaptic plasticity  
involved_in regulation of monoatomic cation transmembrane transport  
involved_in regulation of neuronal synaptic plasticity PubMed 
involved_in regulation of neuronal synaptic plasticity PubMed 
involved_in regulation of postsynaptic cytosolic calcium ion concentration  
acts_upstream_of_or_within regulation of postsynaptic membrane potential PubMed 
acts_upstream_of_or_within regulation of synaptic plasticity PubMed 
involved_in regulation of synaptic plasticity PubMed 
acts_upstream_of_or_within response to ethanol PubMed 
involved_in response to ethanol  
involved_in response to hypoxia  
involved_in rhythmic process  
involved_in sensitization  
acts_upstream_of_or_within sensory organ development PubMed 
acts_upstream_of_or_within startle response PubMed 
acts_upstream_of_or_within startle response PubMed 
acts_upstream_of_or_within suckling behavior PubMed 
involved_in synaptic transmission, glutamatergic  
Items 1 - 25 of 65
Items 1 - 20 of 50
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex PubMed 
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex  
located_in Z disc  
located_in apical dendrite  
located_in cell surface PubMed 
located_in cell surface PubMed 
located_in cell surface  
located_in cytoplasm  
located_in cytoskeleton  
located_in dendrite  
located_in dendritic branch  
located_in dendritic spine  
located_in endoplasmic reticulum membrane  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
is_active_in hippocampal mossy fiber to CA3 synapse  
located_in late endosome PubMed 
located_in lysosome PubMed 
located_in membrane PubMed 
located_in neuron projection PubMed 
located_in neuron projection  
located_in neuronal cell body  
is_active_in parallel fiber to Purkinje cell synapse  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynapse PubMed 
is_active_in postsynaptic density PubMed 
located_in postsynaptic density PubMed 
located_in postsynaptic density  
is_active_in postsynaptic density membrane  
is_active_in postsynaptic density membrane PubMed 
is_active_in postsynaptic density membrane  
located_in postsynaptic density, intracellular component  
located_in postsynaptic membrane PubMed 
located_in postsynaptic membrane PubMed 
is_active_in presynaptic active zone membrane  
located_in presynaptic membrane PubMed 
is_active_in presynaptic membrane  
located_in presynaptic membrane  
located_in synapse PubMed 
located_in synapse  
located_in synaptic cleft  
located_in synaptic membrane PubMed 
located_in synaptic vesicle PubMed 
located_in terminal bouton  
located_in transport vesicle membrane  
Items 1 - 20 of 50

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 2B
Names
N-methyl D-aspartate receptor subtype 2B
glutamate [NMDA] receptor subunit epsilon-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363750.1NP_001350679.1  glutamate receptor ionotropic, NMDA 2B precursor

    Status: VALIDATED

    Source sequence(s)
    AC124500, AC124590, AC132119, AC161364
    Consensus CDS
    CCDS20648.1
    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  2. NM_008171.4NP_032197.3  glutamate receptor ionotropic, NMDA 2B precursor

    See identical proteins and their annotated locations for NP_032197.3

    Status: VALIDATED

    Source sequence(s)
    AC124500, AC124590, AC132119, AC161364
    Consensus CDS
    CCDS20648.1
    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Related
    ENSMUSP00000107536.2, ENSMUST00000111905.8
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135690219..136150658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241221.4XP_011239523.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_011239523.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  2. XM_006505575.5XP_006505638.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505638.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  3. XM_006505574.5XP_006505637.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505637.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  4. XM_006505573.5XP_006505636.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    See identical proteins and their annotated locations for XP_006505636.1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  5. XM_036165858.1XP_036021751.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    UniProtKB/Swiss-Prot
    Q01097, Q9DCB2
    UniProtKB/TrEMBL
    G3X9V4
    Conserved Domains (3) summary
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06378
    Location:33388
    PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
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