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Nr3c1 nuclear receptor subfamily 3, group C, member 1 [ Mus musculus (house mouse) ]

Gene ID: 14815, updated on 14-Jan-2025

Summary

Official Symbol
Nr3c1provided by MGI
Official Full Name
nuclear receptor subfamily 3, group C, member 1provided by MGI
Primary source
MGI:MGI:95824
See related
Ensembl:ENSMUSG00000024431 AllianceGenome:MGI:95824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GR; Grl1; Grl-1
Summary
Enables several functions, including identical protein binding activity; nuclear glucocorticoid receptor activity; and promoter-specific chromatin binding activity. Involved in several processes, including glial cell differentiation; nuclear receptor-mediated glucocorticoid signaling pathway; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including maternal behavior; regulation of primary metabolic process; and response to cortisol. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and leg muscle. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anorexia nervosa; cocaine abuse; heroin dependence; and lung disease (multiple). Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 11.2), subcutaneous fat pad adult (RPKM 8.1) and 28 other tissues See more
Orthologs
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Genomic context

See Nr3c1 in Genome Data Viewer
Location:
18 B3; 18 21.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (39543598..39652485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (39410545..39519421, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene STARR-seq mESC enhancer starr_44401 Neighboring gene predicted gene 15337 Neighboring gene predicted gene, 57770 Neighboring gene STARR-positive B cell enhancer ABC_E10988 Neighboring gene STARR-positive B cell enhancer ABC_E10989 Neighboring gene STARR-seq mESC enhancer starr_44402 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:39679285-39679468 Neighboring gene predicted gene, 54019 Neighboring gene predicted gene, 30909 Neighboring gene predicted gene, 30961

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 41
Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
enables Hsp70 protein binding  
enables Hsp90 protein binding  
enables Hsp90 protein binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
enables TBP-class protein binding  
enables TBP-class protein binding  
enables chromatin binding  
enables core promoter sequence-specific DNA binding  
enables core promoter sequence-specific DNA binding  
enables double-stranded DNA binding  
enables estrogen response element binding  
enables heat shock protein binding  
enables hormone binding  
enables identical protein binding PubMed 
enables nuclear glucocorticoid receptor activity PubMed 
enables nuclear receptor activity  
enables nuclear receptor activity  
enables nuclear receptor activity  
enables promoter-specific chromatin binding PubMed 
enables protein binding PubMed 
enables protein kinase binding PubMed 
enables protein kinase binding  
enables protein-containing complex binding  
enables receptor tyrosine kinase binding  
enables sequence-specific DNA binding PubMed 
enables sequence-specific DNA binding  
enables sequence-specific double-stranded DNA binding  
enables steroid binding  
enables steroid binding  
enables steroid hormone binding  
enables steroid hormone binding  
enables transcription coactivator activity  
enables zinc ion binding  
Items 1 - 25 of 41
Items 1 - 25 of 53
Process Evidence Code Pubs
acts_upstream_of_or_within adrenal gland development PubMed 
involved_in astrocyte differentiation PubMed 
involved_in cellular response to dexamethasone stimulus  
involved_in cellular response to dexamethasone stimulus  
involved_in cellular response to glucocorticoid stimulus  
involved_in cellular response to steroid hormone stimulus  
involved_in cellular response to transforming growth factor beta stimulus  
involved_in cellular response to transforming growth factor beta stimulus  
involved_in chromatin organization  
involved_in chromatin remodeling  
acts_upstream_of_or_within gene expression PubMed 
involved_in gene expression PubMed 
involved_in glucocorticoid mediated signaling pathway  
acts_upstream_of_or_within glucocorticoid metabolic process PubMed 
acts_upstream_of_or_within mammary gland duct morphogenesis PubMed 
acts_upstream_of_or_within maternal behavior PubMed 
involved_in microglia differentiation PubMed 
involved_in motor behavior PubMed 
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of synaptic plasticity  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of vascular permeability  
involved_in neuroinflammatory response PubMed 
involved_in nuclear receptor-mediated corticosteroid signaling pathway  
acts_upstream_of_or_within nuclear receptor-mediated glucocorticoid signaling pathway PubMed 
involved_in nuclear receptor-mediated glucocorticoid signaling pathway PubMed 
acts_upstream_of_or_within nuclear receptor-mediated glucocorticoid signaling pathway PubMed 
involved_in nuclear receptor-mediated steroid hormone signaling pathway  
involved_in positive regulation of cell growth involved in cardiac muscle cell development  
involved_in positive regulation of dendritic spine development  
involved_in positive regulation of glucocorticoid receptor signaling pathway  
involved_in positive regulation of glutamate secretion  
involved_in positive regulation of miRNA transcription PubMed 
involved_in positive regulation of miRNA transcription  
acts_upstream_of_or_within positive regulation of neuron apoptotic process PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
involved_in regulation of DNA-templated transcription PubMed 
involved_in regulation of DNA-templated transcription  
involved_in regulation of cell population proliferation  
acts_upstream_of_or_within regulation of glucocorticoid biosynthetic process PubMed 
acts_upstream_of_or_within regulation of gluconeogenesis PubMed 
involved_in regulation of glucose metabolic process  
involved_in regulation of transcription by RNA polymerase II  
involved_in response to arsenic-containing substance  
involved_in response to corticosterone  
acts_upstream_of_or_within response to cortisol PubMed 
acts_upstream_of_or_within response to wounding PubMed 
involved_in synaptic transmission, glutamatergic PubMed 
involved_in transcription initiation-coupled chromatin remodeling  
Items 1 - 25 of 53
Items 1 - 20 of 24
Component Evidence Code Pubs
located_in centrosome  
located_in chromatin  
located_in chromosome  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytosol PubMed 
located_in cytosol  
located_in dendritic spine  
is_active_in glutamatergic synapse  
located_in intracellular anatomical structure PubMed 
located_in membrane PubMed 
located_in mitochondrion  
located_in nuclear speck  
located_in nuclear speck  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
is_active_in nucleus  
located_in nucleus  
is_active_in postsynaptic density, intracellular component  
part_of protein-containing complex  
part_of protein-containing complex  
located_in spindle  
located_in synapse  
Items 1 - 20 of 24

General protein information

Preferred Names
glucocorticoid receptor
Names
glucocorticoid receptor 1
glucocorticoid receptor subtype P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361209.1NP_001348138.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Related
    ENSMUSP00000111229.2, ENSMUST00000115567.8
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  2. NM_001361210.1NP_001348139.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Related
    ENSMUSP00000111233.2, ENSMUST00000115571.8
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  3. NM_001361211.1NP_001348140.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  4. NM_001361212.1NP_001348141.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  5. NM_008173.4NP_032199.3  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_032199.3

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    39543598..39652485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525658.3XP_006525721.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525721.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  2. XM_006525662.3XP_006525725.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525725.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  3. XM_030250339.2XP_030106199.1  glucocorticoid receptor isoform X2

    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  4. XM_006525664.3XP_006525727.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525727.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  5. XM_006525659.5XP_006525722.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525722.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  6. XM_036160990.1XP_036016883.1  glucocorticoid receptor isoform X2

    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  7. XM_030250338.2XP_030106198.1  glucocorticoid receptor isoform X2

    UniProtKB/Swiss-Prot
    E0ZPU5, E9PUR6, E9PYV1, P06537, Q06VW2, Q3U126, Q3U2M7, Q61628, Q61629
    Related
    ENSMUSP00000025300.7, ENSMUST00000025300.13
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  8. XM_006525661.4XP_006525724.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525724.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  9. XM_006525663.5XP_006525726.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525726.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  10. XM_006525665.5XP_006525728.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525728.1

    UniProtKB/TrEMBL
    E9PYV1
    Related
    ENSMUSP00000095199.3, ENSMUST00000097592.9
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  11. XM_006525660.4XP_006525723.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525723.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
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