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Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C [ Rattus norvegicus (Norway rat) ]

Gene ID: 154516, updated on 4-Jan-2025

Summary

Official Symbol
Ugt1a7cprovided by RGD
Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A7Cprovided by RGD
Primary source
RGD:620950
See related
AllianceGenome:RGD:620950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ugt1; Ugt1a7; Ugt1a8; UDPGT 1-7
Summary
Enables glucuronosyltransferase activity. Involved in several processes, including coumarin catabolic process; estrogen catabolic process; and liver development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A10 (UDP glucuronosyltransferase family 1 member A10); UGT1A7 (UDP glucuronosyltransferase family 1 member A7); and UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 1969.4), Kidney (RPKM 896.9) and 3 other tissues See more
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Genomic context

See Ugt1a7c in Genome Data Viewer
Location:
9q35
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96187382..96256264)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88739577..88808465)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95233957..95302822)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glycosyltransferase 1 family, pseudogene 1 Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity  
enables enzyme binding  
enables glucuronosyltransferase activity PubMed 
Process Evidence Code Pubs
involved_in cellular glucuronidation  
involved_in cellular glucuronidation  
involved_in coumarin catabolic process PubMed 
involved_in estrogen catabolic process PubMed 
involved_in liver development  
involved_in liver development PubMed 
involved_in response to organic cyclic compound PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  

General protein information

Preferred Names
UDP-glucuronosyltransferase 1A7
Names
A2
UDP glucuronosyltransferase 1A7
UDP glycosyltransferase 1 family, polypeptide A7
UDP-glucuronosyltransferase 1-7
UDP-glucuronosyltransferase 1A7C
UDPGT
UGT1*7
UGT1-07
UGT1.7
NP_569091.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130407.2NP_569091.2  UDP-glucuronosyltransferase 1A7 precursor

    See identical proteins and their annotated locations for NP_569091.2

    Status: VALIDATED

    Source sequence(s)
    AC120922, BC078732
    UniProtKB/TrEMBL
    A6JQH7, F7F4L9, Q6T5E8, Q8VD43
    Conserved Domains (2) summary
    PHA03392
    Location:264505
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:26522
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    96187382..96256264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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