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Hs3st1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 15476, updated on 26-Mar-2024

Summary

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Official Symbol
Hs3st1provided by MGI
Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 1provided by MGI
Primary source
MGI:MGI:1201606
See related
Ensembl:ENSMUSG00000051022 AllianceGenome:MGI:1201606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3-Ost; Hsg3ost; D5Wsu110e
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; appendicular skeleton; ear; hindlimb; and nervous system. Orthologous to human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 31.6), lung adult (RPKM 23.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Hs3st1 in Genome Data Viewer
Location:
5 B3; 5 21.14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (39771278..39802791, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (39613935..39645592, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 5 pseudogene Neighboring gene RIKEN cDNA 4930513D17 gene Neighboring gene STARR-seq mESC enhancer starr_12937 Neighboring gene predicted gene, 25377 Neighboring gene STARR-seq mESC enhancer starr_12938 Neighboring gene STARR-positive B cell enhancer mm9_chr5:40022129-40022429 Neighboring gene STARR-positive B cell enhancer ABC_E3573 Neighboring gene STARR-seq mESC enhancer starr_12939 Neighboring gene STARR-seq mESC enhancer starr_12940 Neighboring gene STARR-seq mESC enhancer starr_12941 Neighboring gene STARR-seq mESC enhancer starr_12942 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:40352258-40352559 Neighboring gene predicted gene, 35191

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation. Ferreras L, et al. Biochim Biophys Acta Gen Subj, 2019 May. PMID 30794825
  2. Histochemical analysis of heparan sulfate 3-O-sulfotransferase expression in mouse brain. Yabe T, et al. Methods Mol Biol, 2015. PMID 25325966
  3. Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. Edavettal SC, et al. J Biol Chem, 2004 Jun 11. PMID 15060080
  4. Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes. Shworak NW, et al. Glycoconj J, 2002 May-Jun. PMID 12975616
  5. Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. HajMohammadi S, et al. J Clin Invest, 2003 Apr. PMID 12671048, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of heparan sulfate sulfotransferases was examined by in situ hybridization.
    Title: Histochemical analysis of heparan sulfate 3-O-sulfotransferase expression in mouse brain.
  2. Crystal structure of the binary complex of 3-OST-1 and PAP provide information essential for understanding the biosynthesis of anticoagulant heparan sulfate and the general mechanism of action of heparan sulfate sulfotransferases.
    Title: Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1.
  3. the 3-OST-1 enzyme produces the majority of tissue anticoagulant heparan sulfate
    Title: Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis.
  4. Hs3st1(-/-) mice do not show an obvious procoagulant phenotype.
    Title: Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes.
  5. In this paper a conformational change is described that occurs in heparan sulfate 3-O-sulfotransferase-1 upon binding to heparan sulfate.
    Title: A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 1
Names
heparan sulfate 3-O-sulfotransferase 1
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
NP_001408509.1
NP_001408510.1
NP_034604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421580.1 → NP_001408509.1  heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC098713
    UniProtKB/Swiss-Prot
    O35310

  2. NM_001421581.1 → NP_001408510.1  heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC098713
    UniProtKB/Swiss-Prot
    O35310

  3. NM_010474.2 → NP_034604.1  heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

    See identical proteins and their annotated locations for NP_034604.1

    Status: VALIDATED

    Source sequence(s)
    AK087753, BY585739, CJ144446
    Consensus CDS
    CCDS19257.1
    UniProtKB/Swiss-Prot
    O35310
    Related
    ENSMUSP00000051055.7, ENSMUST00000053116.7
    Conserved Domains (1) summary
    pfam00685
    Location:58 → 295
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    39771278..39802791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35310.1 GenPept UniProtKB/Swiss-Prot:O35310

Gene LinkOut

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