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Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 [ Mus musculus (house mouse) ]

Gene ID: 15531, updated on 8-May-2024

Summary

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Official Symbol
Ndst1provided by MGI
Official Full Name
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1provided by MGI
Primary source
MGI:MGI:104719
See related
Ensembl:ENSMUSG00000054008 AllianceGenome:MGI:104719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsst; HSNST; N-HSST; NDST-1; HSNST 1; N-HSST 1; b2b2230Clo; 1200015G06Rik
Summary
Enables deacetylase activity and sulfotransferase activity. Acts upstream of or within several processes, including animal organ development; positive regulation of signal transduction; and protein sulfation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; future brain; integumental system; nervous system; and respiratory system. Used to study DiGeorge syndrome; congenital diaphragmatic hernia; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 78.1), adrenal adult (RPKM 46.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E1; 18 34.38 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60817566..60907465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60684494..60749035, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene synaptopodin Neighboring gene STARR-seq mESC enhancer starr_44719 Neighboring gene RIKEN cDNA G630071F17 gene Neighboring gene VISTA enhancer mm1623 Neighboring gene STARR-positive B cell enhancer ABC_E7590 Neighboring gene STARR-seq mESC enhancer starr_44724 Neighboring gene STARR-positive B cell enhancer mm9_chr18:60904284-60904585 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:60935339-60935448 Neighboring gene ribosomal protein S14 Neighboring gene 40S ribosomal protein S16 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells. Otsuka T, et al. Stem Cells Dev, 2022 Dec. PMID 35920108, Free PMC Article
  2. Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Ndst Gene Function. Lewejohann L, et al. J Dev Biol, 2020 Jul 11. PMID 32664575, Free PMC Article
  3. Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting. Gupta P, et al. Neoplasia, 2020 Feb. PMID 31896526, Free PMC Article
  4. Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection. Chen H, et al. Sci Rep, 2018 Sep 7. PMID 30194334, Free PMC Article
  5. Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy. Talsma DT, et al. Lab Invest, 2018 Apr. PMID 29330473, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.
    Title: Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.
  2. Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells.
    Title: Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells.
  3. Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.
    Title: Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting.
  4. Transplant of donor allografts with conditional Ndst1 deficiency exhibit significantly reduced acute rejection, comparable to systemic chemokine-GAG inhibition. Modified disaccharides in engrafted organs correlate with reduced rejection.
    Title: Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.
  5. Tubulo-interstitial macrophage influx and fibrosis are reduced by endothelial Ndst1 deficiency in experimental diabetes.
    Title: Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy.
  6. An essential role for Heparin sulfate proteoglycan sulfation via NDST1,2,3 in modulating signal transduction during mouse implantation.
    Title: Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.
  7. Podocyte-glomerular basement membrane interactions and cytoskeletal organization are disrupted in the glomeruli of the Ndst1-/- mutant mouse model
    Title: N-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions.
  8. Although the renal phenotype of the Ndst1(-/-) mouse is mild, the data show that heparan chain N-sulfation plays a key role in podocyte organization.
    Title: Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo.
  9. Targeted ablation of Ndst1 in smooth muscle cells results in altered biomechanical properties of aorta.
    Title: Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1.
  10. Loss of NDST1 causes defective diaphragm vascular development and congenital diaphragmatic hernia.
    Title: Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [heparan sulfate]-glucosamine N-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparan sulfate N-deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparan sulfate N-deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic neurocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycosaminoglycan metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within polysaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein deacetylation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein sulfation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein sulfation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Names
N-heparan sulfate sulfotransferase 1
[Heparan sulfate]-glucosamine N-sulfotransferase 1
NP_001335029.1
NP_001335030.1
NP_001335031.1
NP_001335032.1
NP_001335075.1
NP_032332.2
XP_006525731.1
XP_006525736.1
XP_030106200.1
XP_030106201.1
XP_030106202.1
XP_036016884.1
XP_036016885.1
XP_036016886.1
XP_036016887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348100.1 → NP_001335029.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC139759, AI844370, AK004787, AK035642, BC079561
    Consensus CDS
    CCDS37834.1
    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  2. NM_001348101.1 → NP_001335030.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC139759, AI844370, AK004787, AK035642, BC079561
    Consensus CDS
    CCDS37834.1
    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Related
    ENSMUSP00000126623.2, ENSMUST00000169273.2
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  3. NM_001348102.1 → NP_001335031.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC149216, AI844370, AK004787, AK035642, BC079561
    Consensus CDS
    CCDS37834.1
    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  4. NM_001348103.1 → NP_001335032.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AC149216, AI844370, AK004787, AK035642, BC079561
    Consensus CDS
    CCDS37834.1
    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  5. NM_001348146.1 → NP_001335075.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 3' coding region and differs in the 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC149216, AK035642
    UniProtKB/Swiss-Prot
    Q3UHN9
    Conserved Domains (1) summary
    pfam12062
    Location:30 → 481
    HSNSD; heparan sulfate-N-deacetylase

  6. NM_008306.5 → NP_032332.2  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_032332.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same isoform (1).
    Source sequence(s)
    AI844370, AK004787, AK035642, BC079561
    Consensus CDS
    CCDS37834.1
    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Related
    ENSMUSP00000158312.2, ENSMUST00000237783.2
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60817566..60907465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160991.1 → XP_036016884.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  2. XM_030250341.1 → XP_030106201.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  3. XM_036160993.1 → XP_036016886.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

    Conserved Domains (2) summary
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase
    cl21551
    Location:605 → 798
    Sulfotransfer_3; Sulfotransferase family

  4. XM_006525673.3 → XP_006525736.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X3

    Conserved Domains (2) summary
    pfam00685
    Location:181 → 431
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:1 → 91
    HSNSD; heparan sulfate-N-deacetylase

  5. XM_036160994.1 → XP_036016887.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X3

    Conserved Domains (2) summary
    pfam00685
    Location:181 → 431
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:1 → 91
    HSNSD; heparan sulfate-N-deacetylase

  6. XM_030250340.2 → XP_030106200.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  7. XM_030250342.1 → XP_030106202.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  8. XM_006525668.4 → XP_006525731.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006525731.1

    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase

  9. XM_036160992.1 → XP_036016885.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
    Conserved Domains (2) summary
    pfam00685
    Location:605 → 855
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:30 → 515
    HSNSD; heparan sulfate-N-deacetylase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHN9.2 GenPept UniProtKB/Swiss-Prot:Q3UHN9

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