PATE1 prostate and testis expressed 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PATE1provided by HGNC
Official Full Name: prostate and testis expressed 1provided by HGNC
Primary source: HGNC:HGNC:24664
See related: Ensembl:ENSG00000171053 MIM:606861; AllianceGenome:HGNC:24664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PATE
Summary: Predicted to enable acetylcholine receptor regulator activity. Predicted to be involved in regulation of neurotransmitter receptor activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 11q24.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (125746279..125749867)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (125774917..125778499)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (125616174..125619762)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.
Title: CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.
these results show that PATE1 variant (A1423G) is probably one of the high risk genetic factors for idiopathic asthenozoospermia among males in China
Title: Association of polymorphisms in PATE1 gene with idiopathic asthenozoospermia in Sichuan, China.
PATE1 has a role in sperm-egg penetration and sperm motility
Title: Aged men share the sperm protein PATE1 defect with young asthenozoospermia patients.
PATE proteins are involved in sperm-oolemma fusion and penetration but not sperm-zona binding.
Title: Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction.
analysis of PATE, expressed primarily in prostate and less in testis, and additional PATE-like genes PATE-M, PATE-DJ, and PATE-B
Title: PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484103

PATE__7045 (e-PCR)
- UniSTS:466382

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables acetylcholine receptor regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostate and testis expressed protein 1

Names: expressed in prostate and testis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.