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DAPK3 death associated protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 1613, updated on 4-Jan-2025

Summary

Official Symbol
DAPK3provided by HGNC
Official Full Name
death associated protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:2676
See related
Ensembl:ENSG00000167657 MIM:603289; AllianceGenome:HGNC:2676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLK; ZIP; ZIPK
Summary
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 16.5), prostate (RPKM 15.3) and 25 other tissues See more
Orthologs
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Genomic context

See DAPK3 in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (3958453..3971099, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (3937706..3950355, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3958451..3971097, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATCAY kinesin light chain interacting caytaxin Neighboring gene RNA, 7SL, cytoplasmic 202, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3938329-3939088 Neighboring gene nicotinamide riboside kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3951361-3952130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:3969519-3970148 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3970149-3970780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9864 Neighboring gene microRNA 637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3981471-3982322 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3984027-3984878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3987713-3988214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3988215-3988714 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3998837-3999482 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:4006760-4007651 and GRCh37_chr19:4007652-4008542 Neighboring gene protein inhibitor of activated STAT 4

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
EBI GWAS Catalog
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ36473

Gene Ontology Provided by GOA

Items 1 - 25 of 32
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding PubMed 
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables cAMP response element binding protein binding PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables identical protein binding PubMed 
enables leucine zipper domain binding PubMed 
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
enables protein kinase activity PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity PubMed 
enables ribosomal protein S6 kinase activity  
enables small GTPase binding PubMed 
Items 1 - 25 of 32
Items 1 - 25 of 27
Process Evidence Code Pubs
involved_in apoptotic process PubMed 
involved_in apoptotic process PubMed 
involved_in apoptotic signaling pathway  
involved_in cellular response to type II interferon PubMed 
involved_in chromatin remodeling  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction PubMed 
involved_in negative regulation of translation PubMed 
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of canonical Wnt signaling pathway PubMed 
involved_in positive regulation of cell migration  
involved_in protein autophosphorylation PubMed 
involved_in protein autophosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of DNA-templated transcription  
involved_in regulation of actin cytoskeleton organization PubMed 
involved_in regulation of actin cytoskeleton organization  
involved_in regulation of apoptotic process PubMed 
involved_in regulation of autophagy PubMed 
involved_in regulation of cell motility  
involved_in regulation of cell shape  
involved_in regulation of focal adhesion assembly PubMed 
involved_in regulation of mitotic cell cycle PubMed 
involved_in regulation of mitotic nuclear division  
involved_in regulation of myosin II filament organization  
involved_in regulation of smooth muscle contraction  
Items 1 - 25 of 27
Component Evidence Code Pubs
located_in PML body  
located_in chromosome, centromeric region PubMed 
is_active_in cytoplasm  
located_in cytosol  
located_in midbody PubMed 
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
located_in spindle PubMed 

General protein information

Preferred Names
death-associated protein kinase 3
Names
DAP kinase 3
DAP-like kinase
MYPT1 kinase
ZIP-kinase
zipper-interacting protein kinase
NP_001339.1
NP_001362587.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348.3NP_001339.1  death-associated protein kinase 3

    See identical proteins and their annotated locations for NP_001339.1

    Status: REVIEWED

    Source sequence(s)
    AI654829, AK027590, AK074799, DA748997, HY104892
    Consensus CDS
    CCDS12116.1
    UniProtKB/Swiss-Prot
    A0AVN4, B3KQE2, O43293, Q05JY4
    UniProtKB/TrEMBL
    B3KNJ3
    Related
    ENSP00000442973.1, ENST00000545797.7
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
  2. NM_001375658.1NP_001362587.1  death-associated protein kinase 3

    Status: REVIEWED

    Source sequence(s)
    AC011488
    Consensus CDS
    CCDS12116.1
    UniProtKB/Swiss-Prot
    A0AVN4, B3KQE2, O43293, Q05JY4
    UniProtKB/TrEMBL
    B3KNJ3
    Related
    ENSP00000301264.3, ENST00000301264.7
    Conserved Domains (1) summary
    cd14105
    Location:7275
    STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    3958453..3971099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    3937706..3950355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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