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Itga2 integrin alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 16398, updated on 13-Jan-2025

Summary

Official Symbol
Itga2provided by MGI
Official Full Name
integrin alpha 2provided by MGI
Primary source
MGI:MGI:96600
See related
Ensembl:ENSMUSG00000015533 AllianceGenome:MGI:96600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DX5; GPIa; CD49B
Summary
Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in large intestine adult (RPKM 1.3), placenta adult (RPKM 1.3) and 21 other tissues See more
Orthologs
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Genomic context

See Itga2 in Genome Data Viewer
Location:
13 D2.2; 13 64.61 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (114969617..115068588, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (114833081..114932100, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53802 Neighboring gene predicted gene, 34790 Neighboring gene STARR-seq mESC enhancer starr_35767 Neighboring gene STARR-positive B cell enhancer ABC_E5421 Neighboring gene STARR-positive B cell enhancer mm9_chr13:115621672-115621973 Neighboring gene STARR-seq mESC enhancer starr_35768 Neighboring gene molybdenum cofactor synthesis 2 Neighboring gene predicted gene, 34845 Neighboring gene integrin alpha 1 Neighboring gene STARR-seq mESC enhancer starr_35769 Neighboring gene predicted gene 10734 Neighboring gene pelota mRNA surveillance and ribosome rescue factor Neighboring gene predicted gene, 41075 Neighboring gene predicted gene, 25985

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding PubMed 
enables collagen binding  
enables collagen binding involved in cell-matrix adhesion  
enables collagen binding involved in cell-matrix adhesion  
enables collagen receptor activity  
enables collagen receptor activity  
enables integrin binding  
enables integrin binding  
enables integrin binding  
enables laminin binding  
enables laminin binding  
enables metal ion binding  
enables protein-containing complex binding  
Items 1 - 25 of 58
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin  
involved_in cell adhesion mediated by integrin  
involved_in cell adhesion mediated by integrin  
involved_in cell-cell adhesion  
involved_in cell-matrix adhesion  
involved_in cell-matrix adhesion  
involved_in cell-substrate adhesion  
involved_in cellular response to estradiol stimulus  
involved_in cellular response to mechanical stimulus  
involved_in collagen-activated signaling pathway  
involved_in collagen-activated signaling pathway  
involved_in detection of mechanical stimulus involved in sensory perception of pain  
involved_in detection of mechanical stimulus involved in sensory perception of pain  
involved_in female pregnancy  
involved_in focal adhesion assembly  
involved_in focal adhesion assembly  
involved_in hepatocyte differentiation  
involved_in hypotonic response  
involved_in hypotonic response  
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway  
involved_in mammary gland development  
involved_in mesodermal cell differentiation  
involved_in positive regulation of cell adhesion  
involved_in positive regulation of cell adhesion  
involved_in positive regulation of cell projection organization  
involved_in positive regulation of cell projection organization  
involved_in positive regulation of collagen biosynthetic process  
involved_in positive regulation of collagen biosynthetic process  
involved_in positive regulation of epithelial cell migration  
involved_in positive regulation of epithelial cell migration  
involved_in positive regulation of leukocyte migration  
involved_in positive regulation of leukocyte migration  
involved_in positive regulation of phagocytosis, engulfment  
involved_in positive regulation of phagocytosis, engulfment  
involved_in positive regulation of positive chemotaxis  
involved_in positive regulation of positive chemotaxis  
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of smooth muscle contraction  
involved_in positive regulation of smooth muscle contraction  
involved_in positive regulation of translation  
involved_in positive regulation of translation  
involved_in positive regulation of transmission of nerve impulse  
involved_in positive regulation of transmission of nerve impulse  
involved_in response to L-ascorbic acid  
involved_in response to amine  
involved_in response to hypoxia  
involved_in response to muscle activity  
involved_in response to parathyroid hormone  
involved_in response to xenobiotic stimulus  
involved_in skin morphogenesis  
involved_in skin morphogenesis  
involved_in substrate-dependent cell migration  
involved_in substrate-dependent cell migration  
Items 1 - 25 of 58
Component Evidence Code Pubs
located_in axon  
located_in axon terminus  
located_in axon terminus  
located_in basal part of cell PubMed 
located_in cell projection  
located_in cell surface PubMed 
located_in cell surface  
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
located_in focal adhesion  
located_in focal adhesion  
part_of integrin alpha2-beta1 complex  
part_of integrin alpha2-beta1 complex  
part_of integrin complex  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in plasma membrane  
located_in plasma membrane  
is_active_in presynapse  

General protein information

Preferred Names
integrin alpha-2
Names
CD49 antigen-like family member B
VLA-2 receptor, alpha 2 subunit
collagen receptor
platelet membrane glycoprotein Ia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008396.4NP_032422.2  integrin alpha-2 precursor

    See identical proteins and their annotated locations for NP_032422.2

    Status: VALIDATED

    Source sequence(s)
    CT025598
    Consensus CDS
    CCDS26787.1
    UniProtKB/Swiss-Prot
    Q62163, Q62469, Q6P1C7
    Related
    ENSMUSP00000053891.9, ENSMUST00000056117.10
    Conserved Domains (4) summary
    smart00191
    Location:548601
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:170350
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11521166
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6461057
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    114969617..115068588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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