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Klrc1 killer cell lectin-like receptor subfamily C, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16641, updated on 12-May-2024

Summary

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Official Symbol
Klrc1provided by MGI
Official Full Name
killer cell lectin-like receptor subfamily C, member 1provided by MGI
Primary source
MGI:MGI:1336161
See related
Ensembl:ENSMUSG00000030167 AllianceGenome:MGI:1336161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NKG2A; NKG2B; CD159a
Summary
Predicted to enable MHC class I protein complex binding activity; MHC class Ib receptor activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; positive regulation of natural killer cell degranulation; and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1) and KLRC2 (killer cell lectin like receptor C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Klrc1 in Genome Data Viewer
Location:
6 F3; 6 63.44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129642978..129659815, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129666015..129682852, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily C, member 3 Neighboring gene killer cell lectin-like receptor subfamily C, member 2 Neighboring gene microRNA 680-1 Neighboring gene PQ loop repeat containing pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection. Ely KH, et al. PLoS One, 2014. PMID 25251060, Free PMC Article
  2. Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor. Hall LJ, et al. Mucosal Immunol, 2013 Sep. PMID 23340823
  3. Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors. Battaglia NG, et al. J Immunol, 2022 Aug 1. PMID 35840162, Free PMC Article
  4. Synergized regulation of NK cell education by NKG2A and specific Ly49 family members. Zhang X, et al. Nat Commun, 2019 Nov 1. PMID 31676749, Free PMC Article
  5. Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells. Kamiya T, et al. J Clin Invest, 2019 May 1. PMID 30860984, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
    Title: KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.
  2. Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.
    Title: Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors.
  3. NKG2A downregulation evades the HLA-E cancer immune-checkpoint, and increases the anti-tumor activity of NK cell infusions
    Title: Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells.
  4. Data suggest that NKG2A Receptor (NKG2A) and the inhibitory members of NK cell lectin-like receptor subfamily A (Ly49) family receptors synergize to regulate NK cell education.
    Title: Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
  5. Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A) heterodimeric receptor is widely expressed among M. musculus subspecies musculus.
    Title: Evidence of functional Cd94 polymorphism in a free-living house mouse population.
  6. Liver cNK cells' hyporesponsiveness to stimulation through activating receptors is independent of IL-10, but correlates with decreased NKG2A expression compared to trNK cells.
    Title: Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement.
  7. Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.
    Title: The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells.
  8. NKG2A optimizes CD8(+) T cell responses during an acute poxvirus infection.
    Title: The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
  9. Results demonstrate the immunoregulatory role of CD8(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance.
    Title: Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.
  10. role in NK cell-mediated protection from DSS-induced colitis
    Title: Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables HLA-E specific inhibitory MHC class Ib receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables MHC class I protein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables inhibitory MHC class Ib receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of natural killer cell activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NKG2-A/NKG2-B type II integral membrane protein
Names
Cluster of Differentiation 159a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136068.2 → NP_001129540.1  NKG2-A/NKG2-B type II integral membrane protein isoform 1

    See identical proteins and their annotated locations for NP_001129540.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC171002, AF106008
    Consensus CDS
    CCDS51926.1
    UniProtKB/TrEMBL
    A6H5Z4, Q9Z202
    Related
    ENSMUSP00000032270.7, ENSMUST00000032270.13
    Conserved Domains (1) summary
    cd03593
    Location:128 → 240
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. NM_001288664.1 → NP_001275593.1  NKG2-A/NKG2-B type II integral membrane protein isoform 3

    See identical proteins and their annotated locations for NP_001275593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AC171002, AF106008, AF106009
    Consensus CDS
    CCDS80621.1
    UniProtKB/TrEMBL
    E9QAJ6, Q9WVJ8
    Related
    ENSMUSP00000130762.2, ENSMUST00000169545.8
    Conserved Domains (1) summary
    cd03593
    Location:94 → 206
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  3. NM_010652.2 → NP_034782.1  NKG2-A/NKG2-B type II integral membrane protein isoform 2

    See identical proteins and their annotated locations for NP_034782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC171002, AF106008, AF109784
    Consensus CDS
    CCDS39663.1
    UniProtKB/TrEMBL
    A6H5Z4, Q9WU32
    Related
    ENSMUSP00000114017.2, ENSMUST00000118447.2
    Conserved Domains (1) summary
    cd03593
    Location:111 → 223
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129642978..129659815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321418.1 → XP_017176907.1  NKG2-A/NKG2-B type II integral membrane protein isoform X3

    UniProtKB/TrEMBL
    E9QAJ6, Q9WVJ8
    Conserved Domains (1) summary
    cd03593
    Location:94 → 206
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. XM_011241237.1 → XP_011239539.1  NKG2-A/NKG2-B type II integral membrane protein isoform X2

    See identical proteins and their annotated locations for XP_011239539.1

    UniProtKB/TrEMBL
    A6H5Z4, Q9WU32
    Conserved Domains (1) summary
    cd03593
    Location:111 → 223
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  3. XM_011241236.1 → XP_011239538.1  NKG2-A/NKG2-B type II integral membrane protein isoform X1

    See identical proteins and their annotated locations for XP_011239538.1

    UniProtKB/TrEMBL
    A6H5Z4, Q9Z202
    Conserved Domains (1) summary
    cd03593
    Location:128 → 240
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Nucleotide Protein Strain
Heading Accession and Version

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