U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TIGD2 tigger transposable element derived 2 [ Homo sapiens (human) ]

Gene ID: 166815, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TIGD2provided by HGNC
Official Full Name
tigger transposable element derived 2provided by HGNC
Primary source
HGNC:HGNC:18333
See related
Ensembl:ENSG00000180346 MIM:612973; AllianceGenome:HGNC:18333
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL106
Summary
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (89111169..89114901)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (92442241..92445972)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (90032320..90036052)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 13 member A Neighboring gene uncharacterized LOC124900732 Neighboring gene uncharacterized LOC105377327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:89908831-89909330 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:89928887-89930086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:89977637-89978199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15567 Neighboring gene RNA, U6 small nuclear 907, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr4:90074054-90074582 Neighboring gene uncharacterized LOC124900834

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Members of the pogo superfamily of DNA-mediated transposons in the human genome. Robertson HM. Mol Gen Genet, 1996 Oct 28. PMID 8917322
  2. Tiggers and DNA transposon fossils in the human genome. Smit AF, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643651, Free PMC Article
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp667D1322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tigger transposable element-derived protein 2
Names
epididymis luminal protein 106

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382380.1 → NP_001369309.1  tigger transposable element-derived protein 2

    Status: REVIEWED

    Source sequence(s)
    AC104785
    Consensus CDS
    CCDS3633.1
    UniProtKB/Swiss-Prot
    Q4W5G0
    UniProtKB/TrEMBL
    B3KNK0, V9HWD1
    Conserved Domains (3) summary
    pfam03184
    Location:207 → 385
    DDE_1; DDE superfamily endonuclease
    pfam03221
    Location:76 → 135
    HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
    cl21459
    Location:4 → 52
    HTH; Helix-turn-helix domains

  2. NM_145715.3 → NP_663761.1  tigger transposable element-derived protein 2

    See identical proteins and their annotated locations for NP_663761.1

    Status: REVIEWED

    Source sequence(s)
    AC104785
    Consensus CDS
    CCDS3633.1
    UniProtKB/Swiss-Prot
    Q4W5G0
    UniProtKB/TrEMBL
    B3KNK0, V9HWD1
    Related
    ENSP00000486687.1, ENST00000603357.3
    Conserved Domains (3) summary
    pfam03184
    Location:207 → 385
    DDE_1; DDE superfamily endonuclease
    pfam03221
    Location:76 → 135
    HTH_Tnp_Tc5; Tc5 transposase DNA-binding domain
    cl21459
    Location:4 → 52
    HTH; Helix-turn-helix domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    89111169..89114901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    92442241..92445972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4W5G0.1 GenPept UniProtKB/Swiss-Prot:Q4W5G0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous