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FAM151B family with sequence similarity 151 member B [ Homo sapiens (human) ]

Gene ID: 167555, updated on 5-Mar-2024

Summary

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Official Symbol
FAM151Bprovided by HGNC
Official Full Name
family with sequence similarity 151 member Bprovided by HGNC
Primary source
HGNC:HGNC:33716
See related
Ensembl:ENSG00000152380 AllianceGenome:HGNC:33716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ9217
Summary
Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 1.1), placenta (RPKM 0.4) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q14.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (80488100..80542563)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (80972095..81026566)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (79783919..79838382)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 211, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:79703845-79704643 Neighboring gene zinc finger FYVE-type containing 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:79783523-79784024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:79784025-79784524 Neighboring gene FAM151B divergent transcript Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:79789343-79789929 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:79793017-79793517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:79802930-79803430 Neighboring gene RPS27A pseudogene 9 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:79808370-79809569 Neighboring gene ribosomal protein L7 pseudogene 24 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:79850523-79851153 Neighboring gene ankyrin repeat domain 34B Neighboring gene DBI pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction and characterization of a normalized cDNA library. Soares MB, et al. Proc Natl Acad Sci U S A, 1994 Sep 27. PMID 7937745, Free PMC Article
  2. Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function. Findlay AS, et al. Sci Rep, 2020 Jan 16. PMID 31949211, Free PMC Article
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in photoreceptor cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein FAM151B
Names
AASA9217

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205548.3 → NP_991111.2  protein FAM151B

    See identical proteins and their annotated locations for NP_991111.2

    Status: VALIDATED

    Source sequence(s)
    AY358256, BC131563, T10044
    Consensus CDS
    CCDS4051.1
    UniProtKB/Swiss-Prot
    A2RRE4, Q6UXP7
    Related
    ENSP00000282226.4, ENST00000282226.5
    Conserved Domains (1) summary
    pfam10223
    Location:29 → 263
    DUF2181; Uncharacterized conserved protein (DUF2181)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    80488100..80542563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543235.3 → XP_011541537.1  protein FAM151B isoform X4

    Conserved Domains (1) summary
    pfam10223
    Location:9 → 221
    DUF2181; Uncharacterized conserved protein (DUF2181)

  2. XM_011543234.3 → XP_011541536.1  protein FAM151B isoform X1

    Conserved Domains (1) summary
    pfam10223
    Location:45 → 279
    DUF2181; Uncharacterized conserved protein (DUF2181)

  3. XM_006714564.4 → XP_006714627.2  protein FAM151B isoform X2

    Conserved Domains (1) summary
    pfam10223
    Location:28 → 262
    DUF2181; Uncharacterized conserved protein (DUF2181)

  4. XM_017009166.2 → XP_016864655.1  protein FAM151B isoform X3

  5. XM_017009167.2 → XP_016864656.1  protein FAM151B isoform X3

  6. XM_047416868.1 → XP_047272824.1  protein FAM151B isoform X5

  7. XM_011543236.3 → XP_011541538.1  protein FAM151B isoform X5

    See identical proteins and their annotated locations for XP_011541538.1

    Conserved Domains (1) summary
    pfam10223
    Location:1 → 209
    DUF2181; Uncharacterized conserved protein (DUF2181)

  8. XM_011543237.3 → XP_011541539.1  protein FAM151B isoform X6

    Conserved Domains (1) summary
    pfam10223
    Location:6 → 163
    DUF2181; Uncharacterized conserved protein (DUF2181)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    80972095..81026566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351914.1 → XP_054207889.1  protein FAM151B isoform X4

  2. XM_054351910.1 → XP_054207885.1  protein FAM151B isoform X1

  3. XM_054351911.1 → XP_054207886.1  protein FAM151B isoform X2

  4. XM_054351912.1 → XP_054207887.1  protein FAM151B isoform X3

  5. XM_054351913.1 → XP_054207888.1  protein FAM151B isoform X3

  6. XM_054351915.1 → XP_054207890.1  protein FAM151B isoform X5

  7. XM_054351916.1 → XP_054207891.1  protein FAM151B isoform X5

  8. XM_054351917.1 → XP_054207892.1  protein FAM151B isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXP7.2 GenPept UniProtKB/Swiss-Prot:Q6UXP7

Gene LinkOut

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