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Lrrn2 leucine rich repeat protein 2, neuronal [ Mus musculus (house mouse) ]

Gene ID: 16980, updated on 7-May-2024

Summary

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Official Symbol
Lrrn2provided by MGI
Official Full Name
leucine rich repeat protein 2, neuronalprovided by MGI
Primary source
MGI:MGI:106037
See related
Ensembl:ENSMUSG00000026443 AllianceGenome:MGI:106037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NLRR-2; 5730406J09Rik
Summary
Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including adrenal medulla; gut; nervous system; optic cup; and urinary system. Orthologous to human LRRN2 (leucine rich repeat neuronal 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 20.2), CNS E18 (RPKM 17.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrn2 in Genome Data Viewer
Location:
1 E4; 1 57.69 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132808093..132867743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132880355..132940005)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31101 Neighboring gene predicted gene, 22609 Neighboring gene STARR-seq mESC enhancer starr_02263 Neighboring gene STARR-seq mESC enhancer starr_02264 Neighboring gene STARR-seq mESC enhancer starr_02265 Neighboring gene predicted gene, 31159 Neighboring gene predicted gene, 38687 Neighboring gene STARR-seq mESC enhancer starr_02266 Neighboring gene STARR-seq mESC enhancer starr_02269 Neighboring gene transformed mouse 3T3 cell double minute 4 Neighboring gene STARR-seq mESC enhancer starr_02270 Neighboring gene STARR-positive B cell enhancer ABC_E1560 Neighboring gene predicted gene 29257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Taguchi A, et al. Brain Res Mol Brain Res, 1996 Jan. PMID 8717337
  2. Expression profile of protein kinase C isozymes in preimplantation mouse development. Dehghani H, et al. Reproduction, 2005 Oct. PMID 16183862
  3. The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Haines BP, et al. Dev Biol, 2005 May 15. PMID 15893969
  4. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
  5. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NLRR-2 expression appears to be predominately confined to the adult.
    Title: The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat neuronal protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010732.4 → NP_034862.1  leucine-rich repeat neuronal protein 2 precursor

    See identical proteins and their annotated locations for NP_034862.1

    Status: VALIDATED

    Source sequence(s)
    AK039216, BB342744, BC056458
    Consensus CDS
    CCDS15289.1
    UniProtKB/TrEMBL
    Q6PHP6, Q6US92
    Related
    ENSMUSP00000027706.4, ENSMUST00000027706.4
    Conserved Domains (7) summary
    cd00116
    Location:62 → 288
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:430 → 514
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:337 → 360
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:95 → 118
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:117 → 177
    LRR_8; Leucine rich repeat
    cl11960
    Location:438 → 514
    Ig; Immunoglobulin domain
    cl15307
    Location:369 → 412
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    132808093..132867743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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