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Oxr1 oxidation resistance 1 [ Mus musculus (house mouse) ]

Gene ID: 170719, updated on 9-May-2024

Summary

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Official Symbol
Oxr1provided by MGI
Official Full Name
oxidation resistance 1provided by MGI
Primary source
MGI:MGI:2179326
See related
Ensembl:ENSMUSG00000022307 AllianceGenome:MGI:2179326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C7; C7B; 2210416C20Rik
Summary
Enables oxidoreductase activity. Acts upstream of or within several processes, including adult walking behavior; negative regulation of neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 11.8), cerebellum adult (RPKM 10.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Oxr1 in Genome Data Viewer
Location:
15 B3.1; 15 16.06 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (41310745..41724447)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (41447482..41861051)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38518 Neighboring gene STARR-seq mESC enhancer starr_38519 Neighboring gene predicted gene, 33557 Neighboring gene STARR-seq mESC enhancer starr_38520 Neighboring gene predicted gene, 41312 Neighboring gene STARR-seq mESC enhancer starr_38522 Neighboring gene STARR-seq mESC enhancer starr_38523 Neighboring gene STARR-seq mESC enhancer starr_38524 Neighboring gene STARR-seq mESC enhancer starr_38525 Neighboring gene STARR-seq mESC enhancer starr_38527 Neighboring gene STARR-seq mESC enhancer starr_38528 Neighboring gene STARR-positive B cell enhancer ABC_E10851 Neighboring gene STARR-seq mESC enhancer starr_38530 Neighboring gene STARR-seq mESC enhancer starr_38531 Neighboring gene STARR-seq mESC enhancer starr_38533 Neighboring gene predicted gene, 26854 Neighboring gene STARR-positive B cell enhancer mm9_chr15:41650297-41650598 Neighboring gene STARR-positive B cell enhancer ABC_E7365 Neighboring gene STARR-seq mESC enhancer starr_38536 Neighboring gene STARR-seq mESC enhancer starr_38537 Neighboring gene actin-binding Rho activating protein Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum. Svistunova DM, et al. Free Radic Biol Med, 2019 Jan. PMID 30389497, Free PMC Article
  2. Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. Finelli MJ, et al. Mol Neurobiol, 2019 Mar. PMID 29905912, Free PMC Article
  3. Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina. Natoli R, et al. Invest Ophthalmol Vis Sci, 2008 Oct. PMID 18539939
  4. Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy. Sahu B, et al. Invest Ophthalmol Vis Sci, 2021 Sep 2. PMID 34505865, Free PMC Article
  5. OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation. Yang M, et al. Cell Rep, 2020 Mar 24. PMID 32209476

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy.
    Title: Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy.
  2. Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.
    Title: Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.
  3. this study shows that Oxr1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum
    Title: Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.
  4. we present a dysregulation of metabolites of glucose metabolism at the pre-symptomatic stage in the Oxr1 knockout cerebellum. We then demonstrate that Oxr1 and Gpi1 physically and functionally interact and that the level of Gpi1 oligomerisation is disrupted when Oxr1 is deleted in vivo. Furthermore, we show that Oxr1 modulates the additional and less well-understood roles of Gpi1 as a cytokine and neuroprotective factor.
    Title: Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.
  5. screening a panel of proteins that regulate mitochondrial morphology in bella GCs revealed de-regulation of phospho-Drp1(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein are associated with mitochondria.
    Title: The antioxidant protein Oxr1 influences aspects of mitochondrial morphology.
  6. identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis and disease progression in SOD1-mediated amyotrophic lateral sclerosis
    Title: Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.
  7. up-regulation of Oxr1 in both human and pre-symptomatic mouse models of amyotrophic lateral sclerosis, indicating that Oxr1 is potentially a novel neuroprotective factor in neurodegenerative disease
    Title: Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
  8. The patterns of Oxr1 expression observed suggest that the gene is associated with resistance to hyperoxic challenge and that it acts at the level of the outer segment.
    Title: Expression and role of the early-response gene Oxr1 in the hyperoxia-challenged mouse retina.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103081, MGC107466

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxidation resistance protein 1
Names
nucleolar protein C7
protein C7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130163.1 → NP_001123635.1  oxidation resistance protein 1 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform B) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
    Source sequence(s)
    AC129212, AF324899, AF333985, AK158703
    Consensus CDS
    CCDS49600.1
    UniProtKB/Swiss-Prot
    Q4KMM3
    Related
    ENSMUSP00000087553.6, ENSMUST00000090095.13
    Conserved Domains (3) summary
    smart00584
    Location:589 → 751
    TLDc; domain in TBC and LysM domain containing proteins
    COG1388
    Location:12 → 54
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:12 → 54
    LysM; LysM domain

  2. NM_001130164.1 → NP_001123636.1  oxidation resistance protein 1 isoform C

    See identical proteins and their annotated locations for NP_001123636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform C) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
    Source sequence(s)
    AF333985, AK158703, AW106090, BK006239
    Consensus CDS
    CCDS49601.1
    UniProtKB/TrEMBL
    B1H3M0
    Related
    ENSMUSP00000130456.2, ENSMUST00000166917.3
    Conserved Domains (1) summary
    smart00584
    Location:54 → 216
    TLDc; domain in TBC and LysM domain containing proteins

  3. NM_001130165.2 → NP_001123637.1  oxidation resistance protein 1 isoform D

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform D) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
    Source sequence(s)
    AC129212
    Consensus CDS
    CCDS49599.1
    UniProtKB/TrEMBL
    E9Q0A7
    Related
    ENSMUSP00000126266.2, ENSMUST00000170127.9
    Conserved Domains (3) summary
    smart00584
    Location:670 → 832
    TLDc; domain in TBC and LysM domain containing proteins
    COG1388
    Location:52 → 135
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:93 → 135
    LysM; LysM domain

  4. NM_001130166.1 → NP_001123638.1  oxidation resistance protein 1 isoform E

    See identical proteins and their annotated locations for NP_001123638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (E). Variants 5 and 7 encode the same protein.
    Source sequence(s)
    AF333985, AK158703, BE988908
    Consensus CDS
    CCDS49598.1
    UniProtKB/Swiss-Prot
    Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4
    Related
    ENSMUSP00000105926.3, ENSMUST00000110297.10
    Conserved Domains (3) summary
    smart00584
    Location:704 → 866
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:100 → 142
    LysM; LysM domain
    cl26761
    Location:265 → 549
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  5. NM_001358976.1 → NP_001345905.1  oxidation resistance protein 1 isoform F

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 5. The encoded isoform (F) has a distinct N-terminus and is shorter than isoform E.
    Source sequence(s)
    AC129212
    Conserved Domains (3) summary
    smart00584
    Location:697 → 859
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:93 → 135
    LysM; LysM domain
    pfam09726
    Location:257 → 540
    Macoilin; Transmembrane protein

  6. NM_001358977.1 → NP_001345906.1  oxidation resistance protein 1 isoform E

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 5 and 7 encode the same protein.
    Source sequence(s)
    AC118590, AC129212, AC141481, AC164633
    Consensus CDS
    CCDS49598.1
    UniProtKB/Swiss-Prot
    Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4
    Conserved Domains (3) summary
    smart00584
    Location:704 → 866
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:100 → 142
    LysM; LysM domain
    cl26761
    Location:265 → 549
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  7. NM_001358978.1 → NP_001345907.1  oxidation resistance protein 1 isoform G

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an exon in the coding region, compared to variant 1. The encoded isoform (G) is shorter, compared to isoform E.
    Source sequence(s)
    AC118590, AC129212, AC141481, AC164633
    Consensus CDS
    CCDS88760.1
    Related
    ENSMUSP00000155237.2, ENSMUST00000230203.2
    Conserved Domains (3) summary
    smart00584
    Location:677 → 839
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:100 → 142
    LysM; LysM domain
    cl26761
    Location:265 → 549
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  8. NM_130885.2 → NP_570955.1  oxidation resistance protein 1 isoform A

    See identical proteins and their annotated locations for NP_570955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform A) with a shorter and distinct N-terminus, compared to isoform E.
    Source sequence(s)
    AC129212
    Consensus CDS
    CCDS27448.1
    UniProtKB/Swiss-Prot
    Q4KMM3
    Related
    ENSMUSP00000022918.8, ENSMUST00000022918.15
    Conserved Domains (3) summary
    smart00584
    Location:616 → 778
    TLDc; domain in TBC and LysM domain containing proteins
    COG1388
    Location:12 → 54
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:12 → 54
    LysM; LysM domain

RNA

  1. NR_152565.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate internal exon, compared to variant 5. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC118590, AC129212, AC141481, AC164633

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    41310745..41724447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159205.1 → XP_036015098.1  oxidation resistance protein 1 isoform X2

    Conserved Domains (3) summary
    smart00584
    Location:690 → 852
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:278 → 562
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:113 → 155
    LysM; LysM domain

  2. XM_030248362.2 → XP_030104222.1  oxidation resistance protein 1 isoform X4

    Conserved Domains (3) summary
    smart00584
    Location:635 → 797
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:196 → 480
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:31 → 73
    LysM; LysM domain

  3. XM_036159206.1 → XP_036015099.1  oxidation resistance protein 1 isoform X4

    Conserved Domains (3) summary
    smart00584
    Location:635 → 797
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:196 → 480
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:31 → 73
    LysM; LysM domain

  4. XM_036159204.1 → XP_036015097.1  oxidation resistance protein 1 isoform X1

    Conserved Domains (3) summary
    smart00584
    Location:717 → 879
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:278 → 562
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:113 → 155
    LysM; LysM domain

  5. XM_036159207.1 → XP_036015100.1  oxidation resistance protein 1 isoform X5

    Conserved Domains (3) summary
    smart00584
    Location:608 → 770
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:196 → 480
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:31 → 73
    LysM; LysM domain

  6. XM_036159209.1 → XP_036015102.1  oxidation resistance protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A2R8W6N3
    Related
    ENSMUSP00000155161.2, ENSMUST00000230778.2
    Conserved Domains (2) summary
    COG5271
    Location:278 → 562
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:113 → 155
    LysM; LysM domain

  7. XM_006520526.5 → XP_006520589.1  oxidation resistance protein 1 isoform X3

    Conserved Domains (3) summary
    smart00584
    Location:637 → 799
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:198 → 482
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:33 → 75
    LysM; LysM domain

  8. XM_006520531.3 → XP_006520594.1  oxidation resistance protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A2R8VHT3
    Related
    ENSMUSP00000155424.2, ENSMUST00000230131.2
    Conserved Domains (1) summary
    smart00584
    Location:81 → 243
    TLDc; domain in TBC and LysM domain containing proteins

RNA

  1. XR_004938803.1 RNA Sequence

  2. XR_004938802.1 RNA Sequence

  3. XR_001781499.2 RNA Sequence

  4. XR_004938804.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KMM3.3 GenPept UniProtKB/Swiss-Prot:Q4KMM3

Gene LinkOut

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