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Snrk SNF related kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 170837, updated on 5-Mar-2024

Summary

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Official Symbol
Snrkprovided by RGD
Official Full Name
SNF related kinaseprovided by RGD
Primary source
RGD:69653
See related
Ensembl:ENSRNOG00000004050 AllianceGenome:RGD:69653
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in nucleus. Orthologous to human SNRK (SNF related kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 279.9), Brain (RPKM 275.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snrk in Genome Data Viewer
Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130657204..130711461)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121779704..121833949)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130749806..130805225)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) Neighboring gene uncharacterized LOC134480254 Neighboring gene uncharacterized LOC134480253 Neighboring gene uncharacterized LOC120094304 Neighboring gene anoctamin 10 Neighboring gene uncharacterized LOC134480255 Neighboring gene uncharacterized LOC102552874

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction. Wang ZY, et al. Cell Death Differ, 2022 Apr. PMID 34621049, Free PMC Article
  2. SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons. Yoshida K, et al. Brain Res, 2000 Aug 11. PMID 10930554
  3. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. Becker W, et al. Eur J Biochem, 1996 Feb 1. PMID 8654423
  4. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Kertesz N, et al. Gene, 2002 Jul 10. PMID 12234663
  5. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. Lefebvre DL, et al. Biochem J, 2001 Apr 15. PMID 11284715, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction.
    Title: Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SNF-related serine/threonine-protein kinase
Names
SNF1-related kinase
NP_620188.1
XP_006244124.1
XP_038936666.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138833.1 → NP_620188.1  SNF-related serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_620188.1

    Status: PROVISIONAL

    Source sequence(s)
    X89383
    UniProtKB/Swiss-Prot
    Q63553
    UniProtKB/TrEMBL
    A6I473
    Related
    ENSRNOP00000071648.1, ENSRNOT00000079273.2
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    130657204..130711461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244062.4 → XP_006244124.1  SNF-related serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006244124.1

    UniProtKB/Swiss-Prot
    Q63553
    UniProtKB/TrEMBL
    A6I473
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  2. XM_039080738.2 → XP_038936666.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q63553
    UniProtKB/TrEMBL
    A6I473
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63553.1 GenPept UniProtKB/Swiss-Prot:Q63553

Gene LinkOut

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