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Ppp1r14c protein phosphatase 1, regulatory (inhibitor) subunit 14c [ Rattus norvegicus (Norway rat) ]

Gene ID: 171010, updated on 2-May-2024

Summary

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Official Symbol
Ppp1r14cprovided by RGD
Official Full Name
protein phosphatase 1, regulatory (inhibitor) subunit 14cprovided by RGD
Primary source
RGD:620538
See related
Ensembl:ENSRNOG00000016368 AllianceGenome:RGD:620538
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kepi
Summary
Enables protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity and regulation of phosphorylation. Located in membrane. Orthologous to human PPP1R14C (protein phosphatase 1 regulatory inhibitor subunit 14C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 360.5), Lung (RPKM 102.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r14c in Genome Data Viewer
Location:
1p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (42177977..42358654)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (39773403..39886970)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (39811314..39923071)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100095 Neighboring gene uncharacterized LOC102555832 Neighboring gene iodotyrosine deiodinase Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene 60S ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. Liu QR, et al. J Biol Chem, 2002 Apr 12. PMID 11812771
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. regulation by morphine
    Title: KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93087

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 14C
Names
PKC-potentiated PP1 inhibitory protein
kinase-enhanced PP1 inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133425.3 → NP_596916.1  protein phosphatase 1 regulatory subunit 14C

    See identical proteins and their annotated locations for NP_596916.1

    Status: PROVISIONAL

    Source sequence(s)
    AF407168
    UniProtKB/Swiss-Prot
    Q8R4R9
    UniProtKB/TrEMBL
    A6KIK0
    Related
    ENSRNOP00000022046.2, ENSRNOT00000022046.4
    Conserved Domains (1) summary
    pfam05361
    Location:70 → 164
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    42177977..42358654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273005.1 → XP_063129075.1  protein phosphatase 1 regulatory subunit 14C isoform X1

  2. XM_039085420.2 → XP_038941348.1  protein phosphatase 1 regulatory subunit 14C isoform X2

    Conserved Domains (1) summary
    pfam05361
    Location:42 → 105
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RNA

  1. XR_010057354.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4R9.1 GenPept UniProtKB/Swiss-Prot:Q8R4R9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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