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Pou2f1 POU class 2 homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171068, updated on 2-May-2024

Summary

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Official Symbol
Pou2f1provided by RGD
Official Full Name
POU class 2 homeobox 1provided by RGD
Primary source
RGD:621689
See related
Ensembl:ENSRNOG00000003581 AllianceGenome:RGD:621689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables chromatin binding activity; signaling receptor binding activity; and transcription cis-regulatory region binding activity. Involved in liver regeneration and negative regulation of gene expression. Located in nucleus. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 59.6), Spleen (RPKM 48.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pou2f1 in Genome Data Viewer
Location:
13q23
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80653602..80796279, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78120617..78263306, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (84075316..84217368, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene cellular repressor of E1A-stimulated genes 1 Neighboring gene Cd247 molecule Neighboring gene uncharacterized LOC134481526 Neighboring gene serine/threonine/tyrosine interacting like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of the rat CYP4A2 gene promoter by c-Jun and octamer binding protein-1. Fiala-Beer E, et al. Int J Biochem Cell Biol, 2007. PMID 17481938
  2. Oct-1 transcription factor is a negative regulator of rat CYP1A1 expression via an octamer sequence in its negative regulatory element. Sterling K, et al. Mol Pharmacol, 1996 Feb. PMID 8632766
  3. The POU-domain protein Oct-1 is widely expressed in adult rat organs. Kambe F, et al. Biochim Biophys Acta, 1993 Jan 23. PMID 8424955
  4. Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver interacts with a ubiquitous transcription/replication factor Oct-1. Timchenko NA, et al. Biomed Sci, 1991. PMID 1841628
  5. Cloning and sequencing of the rat Oct-1 POU box. Lillycrop KA, et al. Nucleic Acids Res, 1991 Jul 11. PMID 1677182, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
    Title: POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
  2. Data show that cAMP elevation reduces nuclear Oct-1 content in primary pancreatic islet cells.
    Title: POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.
  3. acts as the activator of the CYP2D4
    Title: A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.
  4. Oct-1 and the TALE homeodomain proteins have roles in regulating the expression of the GnRH gene in neurons
    Title: TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lens induction in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within olfactory placode formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
POU domain, class 2, transcription factor 1
Names
NF-A1
OTF-1
oct-1
octamer-binding protein 1
octamer-binding transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100639.1 → NP_001094109.1  POU domain, class 2, transcription factor 1

    See identical proteins and their annotated locations for NP_001094109.1

    Status: VALIDATED

    Source sequence(s)
    DV214198, U17013
    UniProtKB/TrEMBL
    A6IDI7, F1LRD7
    Related
    ENSRNOP00000044416.5, ENSRNOT00000047488.6
    Conserved Domains (2) summary
    smart00352
    Location:303 → 377
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:407 → 460
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    80653602..80796279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769599.4 → XP_008767821.1  POU domain, class 2, transcription factor 1 isoform X2

    See identical proteins and their annotated locations for XP_008767821.1

    UniProtKB/TrEMBL
    A0A0G2K3N5, A6IDI6, F1LRD7
    Related
    ENSRNOP00000072711.1
    Conserved Domains (2) summary
    smart00352
    Location:303 → 377
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:407 → 461
    Homeobox; Homeobox domain

  2. XM_039090304.2 → XP_038946232.1  POU domain, class 2, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    F1LRD7
    Conserved Domains (2) summary
    smart00352
    Location:280 → 354
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:384 → 438
    Homeobox; Homeobox domain

  3. XM_039090301.2 → XP_038946229.1  POU domain, class 2, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    F1LRD7
    Conserved Domains (2) summary
    smart00352
    Location:280 → 354
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:384 → 438
    Homeobox; Homeobox domain

  4. XM_017598656.3 → XP_017454145.1  POU domain, class 2, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    F1LRD7
    Conserved Domains (2) summary
    smart00352
    Location:280 → 354
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:384 → 438
    Homeobox; Homeobox domain

  5. XM_039090298.2 → XP_038946226.1  POU domain, class 2, transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    F1LRD7
    Conserved Domains (2) summary
    smart00352
    Location:280 → 354
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:384 → 438
    Homeobox; Homeobox domain

  6. XM_063271991.1 → XP_063128061.1  POU domain, class 2, transcription factor 1 isoform X4

  7. XM_063271989.1 → XP_063128059.1  POU domain, class 2, transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEY3, A6IDI8

  8. XM_063271990.1 → XP_063128060.1  POU domain, class 2, transcription factor 1 isoform X3

RNA

  1. XR_005492198.2 RNA Sequence

  2. XR_005492197.2 RNA Sequence

  3. XR_595497.4 RNA Sequence

  4. XR_005492196.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31503.2 GenPept UniProtKB/Swiss-Prot:P31503

Gene LinkOut

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