Zbp1 Z-DNA binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zbp1provided by RGD
Official Full Name: Z-DNA binding protein 1provided by RGD
Primary source: RGD:619956
See related: Ensembl:ENSRNOG00000006314 AllianceGenome:RGD:619956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlm1
Summary: Predicted to enable double-stranded RNA binding activity; identical protein binding activity; and left-handed Z-DNA binding activity. Predicted to be involved in several processes, including positive regulation of defense response; positive regulation of programmed cell death; and regulation of interleukin-1-mediated signaling pathway. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human ZBP1 (Z-DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 29.5), Thymus (RPKM 27.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (182411665..182427604, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (161993351..162009297, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (171276062..171292062, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of ZBP1 in eccentric exercise-induced skeletal muscle necroptosis.
Title: The role of ZBP1 in eccentric exercise-induced skeletal muscle necroptosis.
ZBP1 mediates the progression of Alzheimer's disease via pyroptosis by regulating IRF3.
Title: ZBP1 mediates the progression of Alzheimer's disease via pyroptosis by regulating IRF3.
LncRNA PVT1 mediates the progression of liver necroptosis via ZBP1 promoter methylation under nonylphenol exposure.
Title: LncRNA PVT1 mediates the progression of liver necroptosis via ZBP1 promoter methylation under nonylphenol exposure.
Ser181 ZBP1 phosphorylation was essential for the proper dendritic branching of hippocampal neurons that were cultured in vitro and for the proper ZBP1 dendritic distribution and motility.
Title: ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons.
Both ZBP1 and HuD bind the zipcode element in rat beta-actin mRNA's 3' UTR. Differences between HuD and ZBP1 were observed in their binding preference to the element.
Title: Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1.
an AU-rich regulatory element (ARE) in GAP-43's 3'UTR is necessary and sufficient for axonal localization of Zbp1
Title: A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135435 (e-PCR)
- UniSTS:218712

D3Mco78 (e-PCR)
- UniSTS:517988

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables left-handed Z-DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in defense response to fungus	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pyroptosis	ISO Inferred from Sequence Orthology more info
involved_in pyroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Z-DNA-binding protein 1

Names: tumor stroma and activated macrophage protein DLM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133564.1 → NP_598248.1 Z-DNA-binding protein 1

See identical proteins and their annotated locations for NP_598248.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8VDA5

UniProtKB/TrEMBL

A0A0G2JZL0, A6KL00

Related

ENSRNOP00000071089.1, ENSRNOT00000081036.2

Conserved Domains (1) summary

cl02659
Location:10 → 68

z-alpha; Adenosine deaminase z-alpha domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

182411665..182427604 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104192.2 → XP_038960120.1 Z-DNA-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8VDA5

UniProtKB/TrEMBL

A0A0G2JZL0, A6KL00

Conserved Domains (1) summary

cl02659
Location:10 → 68

z-alpha; Adenosine deaminase z-alpha domain
XM_006235674.5 → XP_006235736.1 Z-DNA-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_006235736.1

UniProtKB/Swiss-Prot

Q8VDA5

UniProtKB/TrEMBL

A0A0G2JZL0, A6KL00

Conserved Domains (1) summary

cl02659
Location:10 → 68

z-alpha; Adenosine deaminase z-alpha domain
XM_039104191.2 → XP_038960119.1 Z-DNA-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8VDA5

UniProtKB/TrEMBL

A0A0G2JZL0, A6KL00

Conserved Domains (1) summary

cl02659
Location:10 → 68

z-alpha; Adenosine deaminase z-alpha domain
XM_039104189.2 → XP_038960117.1 Z-DNA-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8VDA5

UniProtKB/TrEMBL

A0A0G2JZL0, A6KL00

Conserved Domains (1) summary

cl02659
Location:10 → 68

z-alpha; Adenosine deaminase z-alpha domain
XM_039104190.2 → XP_038960118.1 Z-DNA-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8VDA5

UniProtKB/TrEMBL

A0A0G2JZL0, A6KL00

Conserved Domains (1) summary

cl02659
Location:10 → 68

z-alpha; Adenosine deaminase z-alpha domain