U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wfdc1 WAP four-disulfide core domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171112, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Wfdc1provided by RGD
Official Full Name
WAP four-disulfide core domain 1provided by RGD
Primary source
RGD:68938
See related
AllianceGenome:RGD:68938
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ps20
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of epithelial cell proliferation; regulation of cell growth; and response to estradiol. Located in extracellular space. Orthologous to human WFDC1 (WAP four-disulfide core domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 380.7), Lung (RPKM 370.6) and 7 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64628689..64647739)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47720191..47739121)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52313771..52332721)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene adenosine deaminase domain containing 2 Neighboring gene potassium voltage-gated channel modifier subfamily G member 4 Neighboring gene transfer RNA alanine (anticodon AGC) 94 Neighboring gene ATPase secretory pathway Ca2+ transporting 2 Neighboring gene uncharacterized LOC102549202

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Suppression of ps20 expression in the rat uterus by tamoxifen and estrogens. Hung H. Endocrinology, 2005 May. PMID 15677758
  2. Decreased stromal expression and increased epithelial expression of WFDC1/ps20 in prostate cancer is associated with reduced recurrence-free survival. McAlhany SJ, et al. Prostate, 2004 Oct 1. PMID 15305341
  3. Molecular cloning and expression of ps20 growth inhibitor. A novel WAP-type "four-disulfide core" domain protein expressed in smooth muscle. Larsen M, et al. J Biol Chem, 1998 Feb 20. PMID 9468514
  4. Purification of a novel protein (ps20) from urogenital sinus mesenchymal cells with growth inhibitory properties in vitro. Rowley DR, et al. J Biol Chem, 1995 Sep 15. PMID 7665628
  5. WFDC1 is a key modulator of inflammatory and wound repair responses. Ressler SJ, et al. Am J Pathol, 2014 Nov. PMID 25219356, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
WAP four-disulfide core domain protein 1
Names
20-kDa prostate stromal protein
prostate stromal protein ps20
ps20 growth inhibitor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133581.2 → NP_598265.1  WAP four-disulfide core domain protein 1 precursor

    See identical proteins and their annotated locations for NP_598265.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    O70280
    UniProtKB/TrEMBL
    A6IZK1
    Conserved Domains (1) summary
    pfam00095
    Location:70 → 98
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    64628689..64647739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255705.4 → XP_006255767.1  WAP four-disulfide core domain protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006255767.1

    UniProtKB/Swiss-Prot
    O70280
    UniProtKB/TrEMBL
    A6IZK1
    Conserved Domains (1) summary
    pfam00095
    Location:70 → 98
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70280.1 GenPept UniProtKB/Swiss-Prot:O70280

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous