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Rph3al rabphilin 3A-like (without C2 domains) [ Rattus norvegicus (Norway rat) ]

Gene ID: 171123, updated on 5-Mar-2024

Summary

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Official Symbol
Rph3alprovided by RGD
Official Full Name
rabphilin 3A-like (without C2 domains)provided by RGD
Primary source
RGD:620342
See related
Ensembl:ENSRNOG00000061429 AllianceGenome:RGD:620342
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Noc2
Summary
Enables LIM domain binding activity. Involved in positive regulation of protein secretion and response to xenobiotic stimulus. Located in secretory granule membrane. Orthologous to human RPH3AL (rabphilin 3A like (without C2 domains)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 52.8), Adrenal (RPKM 35.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rph3al in Genome Data Viewer
Location:
10q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (61188288..61331591, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60689943..60833354, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63989556..64140584, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene double C2 domain beta Neighboring gene uncharacterized LOC134480823 Neighboring gene uncharacterized LOC102549294 Neighboring gene uncharacterized LOC102549419 Neighboring gene uncharacterized LOC120095141 Neighboring gene uncharacterized LOC134480824 Neighboring gene ligand of ATE1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes. Koumanov F, et al. Diabetologia, 2015 Aug. PMID 26024738, Free PMC Article
  2. Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells. Imai A, et al. Arch Biochem Biophys, 2006 Nov 15. PMID 17067543
  3. Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. Kotake K, et al. J Biol Chem, 1997 Nov 21. PMID 9367993
  4. The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells. Handley MT, et al. Biochem Biophys Res Commun, 2008 Aug 22. PMID 18573236
  5. A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells. Haynes LP, et al. J Biol Chem, 2001 Mar 30. PMID 11134008

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. discovery of the involvement of Rab3 and Noc2 in an insulin-regulated step in GLUT4 translocation suggests that the control of this translocation process is unexpectedly similar to regulated secretion and particularly pancreatic insulin-vesicle release.
    Title: Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.
  2. Three Rab3/27 effectors, Granuphilin, Noc2, and Rabphilin, in PC12 cells using fluorescence recovery after photobleaching of EGFP-tagged proteins.
    Title: The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.
  3. Our results suggest that the Noc2/Rab27 complex is an important constituent of the early stages of IPR-stimulated amylase release.
    Title: Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells.
  4. Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in rat cells
    Title: Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
  5. Noc2 is a potential partner of Munc13, a component of the machinery that controls vesicle priming and insulin exocytosis
    Title: The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables LIM domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spontaneous neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rab effector Noc2
Names
no C2 domains protein
rabphilin-3A-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133591.2 → NP_598275.1  rab effector Noc2

    See identical proteins and their annotated locations for NP_598275.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091126
    UniProtKB/Swiss-Prot
    O54880
    UniProtKB/TrEMBL
    A6HGU0
    Related
    ENSRNOP00000075521.1, ENSRNOT00000081725.2
    Conserved Domains (1) summary
    pfam02318
    Location:45 → 159
    FYVE_2; FYVE-type zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    61188288..61331591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085148.2 → XP_038941076.1  rab effector Noc2 isoform X2

    Conserved Domains (1) summary
    cl22851
    Location:45 → 130
    PHD_SF; PHD finger superfamily

  2. XM_008767942.4 → XP_008766164.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_008766164.1

    UniProtKB/Swiss-Prot
    O54880
    UniProtKB/TrEMBL
    A6HGU0
    Conserved Domains (1) summary
    pfam02318
    Location:45 → 159
    FYVE_2; FYVE-type zinc finger

  3. XM_063268370.1 → XP_063124440.1  rab effector Noc2 isoform X2

  4. XM_063268369.1 → XP_063124439.1  rab effector Noc2 isoform X2

  5. XM_008767941.4 → XP_008766163.1  rab effector Noc2 isoform X1

    See identical proteins and their annotated locations for XP_008766163.1

    UniProtKB/Swiss-Prot
    O54880
    UniProtKB/TrEMBL
    A6HGU0
    Conserved Domains (1) summary
    pfam02318
    Location:45 → 159
    FYVE_2; FYVE-type zinc finger

  6. XM_063268374.1 → XP_063124444.1  rab effector Noc2 isoform X6

  7. XM_039085152.2 → XP_038941080.1  rab effector Noc2 isoform X5

    Conserved Domains (1) summary
    cl28890
    Location:15 → 65
    FYVE_like_SF; FYVE domain like superfamily

  8. XM_063268373.1 → XP_063124443.1  rab effector Noc2 isoform X5

  9. XM_063268371.1 → XP_063124441.1  rab effector Noc2 isoform X3

  10. XM_063268372.1 → XP_063124442.1  rab effector Noc2 isoform X4

RNA

  1. XR_010055126.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54880.1 GenPept UniProtKB/Swiss-Prot:O54880

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