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Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) [ Mus musculus (house mouse) ]

Gene ID: 17134, updated on 12-May-2024

Summary

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Official Symbol
Mafgprovided by MGI
Official Full Name
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)provided by MGI
Primary source
MGI:MGI:96911
See related
Ensembl:ENSMUSG00000051510 AllianceGenome:MGI:96911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C630022N07Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult behavior; in utero embryonic development; and regulation of epidermal cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MAFG (MAF bZIP transcription factor G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 18.1), adrenal adult (RPKM 17.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mafg in Genome Data Viewer
Location:
11 E2; 11 84.35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120515943..120525771, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120625117..120634955, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene STARR-positive B cell enhancer ABC_E7114 Neighboring gene sirtuin 7 Neighboring gene microRNA 6936 Neighboring gene STARR-positive B cell enhancer ABC_E7115 Neighboring gene predicted gene, 17586 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:120504984-120505285 Neighboring gene myeloid-associated differentiation marker-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intrinsic and extrinsic effects of mafG deficiency on hematopoietic recovery following bone marrow transplant. Li XM, et al. Exp Hematol, 2010 Dec. PMID 20813153
  2. Structural basis of alternative DNA recognition by Maf transcription factors. Kurokawa H, et al. Mol Cell Biol, 2009 Dec. PMID 19797082, Free PMC Article
  3. Use of the pinna reflex as a test of hearing in mutant mice. Cheatham MA, et al. Audiol Neurootol, 2001 Mar-Apr. PMID 11385181
  4. Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells. Katsuoka F, et al. Mol Cell Biol, 2019 Oct 15. PMID 31383749, Free PMC Article
  5. miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells. Caggiano R, et al. Oxid Med Cell Longev, 2017. PMID 29138682, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing Mafg in mouse hepatocytes and obese mice elicits a fasting-like gene expression profile, improves glucose metabolism.
    Title: A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
  2. results provide direct evidence that the Nrf2-MafG heterodimer acts as a transcriptional activator of Nrf2-dependent genes
    Title: Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells.
  3. In condition of hypoxia, MAFG induction correlated with reduced levels of miR-128. This lead to increased mRNA levels of HMOX-1 and x-CT for blunting stress. Overall, these findings identify MAFG as novel direct target of miR-128.
    Title: miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells.
  4. The CNC-sMaf binding element is strictly required for the Nrf2-sMaf heterodimer function in cytoprotection.
    Title: Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection.
  5. The MafG as an FXR target gene and show that hepatic MAFG expression represses genes of the bile acid synthetic pathway and modifies the biliary bile acid composition.
    Title: MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
  6. These data identify Mafg and Mafk as new cataract-associated candidates and define their function in regulating largely non-crystallin genes linked to human cataract.
    Title: Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract.
  7. These findings demonstrate that a combination of p45NF-E2, Maf G, and Maf K is a key determinant of both megakaryopoiesis and thrombopoiesis.
    Title: Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf.
  8. MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
    Title: Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
  9. The MafG C terminus is essential for proplatelet formation and platelet gene activation but not for p45 binding to the Maf recognition element (MARE).
    Title: Molecular determinants for small Maf protein control of platelet production.
  10. mafG expression has intrinsic and extrinsic effects on hematopoietic engraftment following bone marrow transplantation.
    Title: Intrinsic and extrinsic effects of mafG deficiency on hematopoietic recovery following bone marrow transplant.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epidermal cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of epidermal cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription factor MafG
Names
V-maf musculoaponeurotic fibrosarcoma oncogene homolog G
avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010756.3 → NP_034886.1  transcription factor MafG

    See identical proteins and their annotated locations for NP_034886.1

    Status: VALIDATED

    Source sequence(s)
    BC052633
    Consensus CDS
    CCDS25748.1
    UniProtKB/Swiss-Prot
    O54790
    Related
    ENSMUSP00000053899.8, ENSMUST00000058162.14
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120515943..120525771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245626.2 → XP_030101486.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    O54790
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  2. XM_030245627.2 → XP_030101487.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    O54790
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  3. XM_017314308.3 → XP_017169797.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    O54790
    Related
    ENSMUSP00000101788.2, ENSMUST00000106182.8
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  4. XM_036156373.1 → XP_036012266.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    O54790
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  5. XM_017314307.2 → XP_017169796.1  transcription factor MafG isoform X1

    Conserved Domains (1) summary
    cd14717
    Location:103 → 172
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  6. XM_017314309.2 → XP_017169798.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    O54790
    Related
    ENSMUSP00000101787.2, ENSMUST00000106181.8
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

  7. XM_017314311.3 → XP_017169800.1  transcription factor MafG isoform X2

    UniProtKB/Swiss-Prot
    O54790
    Conserved Domains (1) summary
    cd14717
    Location:46 → 115
    bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54790.1 GenPept UniProtKB/Swiss-Prot:O54790

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