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Spata6 spermatogenesis associated 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171413, updated on 19-May-2024

Summary

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Official Symbol
Spata6provided by RGD
Official Full Name
spermatogenesis associated 6provided by RGD
Primary source
RGD:628657
See related
Ensembl:ENSRNOG00000007568 AllianceGenome:RGD:628657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hash
Summary
Predicted to enable myosin light chain binding activity. Predicted to be involved in motile cilium assembly and spermatogenesis. Predicted to be located in extracellular region. Predicted to be active in sperm connecting piece. Orthologous to human SPATA6 (spermatogenesis associated 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 1846.8) and Lung (RPKM 72.1) See more
Orthologs
human mouse all
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Genomic context

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See Spata6 in Genome Data Viewer
Location:
5q35
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (131821585..131905011)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (126593122..126676557)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (131719922..131803853)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ELAV like RNA binding protein 4 Neighboring gene AGBL carboxypeptidase 4 Neighboring gene BEN domain containing 5 Neighboring gene solute carrier family 5 member 9 Neighboring gene selection and upkeep of intraepithelial T cells 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6). Oh C, et al. Mol Hum Reprod, 2003 Jun. PMID 12771232
  2. A novel spermatogenesis-related factor-1 gene expressed in maturing rat testis. Yamano Y, et al. Biochem Biophys Res Commun, 2001 Dec 14. PMID 11735130
  3. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Yuan S, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605924, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables myosin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin light chain binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin light chain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm connecting piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm connecting piece IEA
Inferred from Electronic Annotation
more info
  
located_in sperm connecting piece ISO
Inferred from Sequence Orthology
more info
  
located_in sperm connecting piece ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 6
Names
kinesin-related protein HASH
spermatogenesis-related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134392.2 → NP_599219.2  spermatogenesis-associated protein 6 precursor

    See identical proteins and their annotated locations for NP_599219.2

    Status: VALIDATED

    Source sequence(s)
    BC158581, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    A0JN12, Q99MU5, Q9EQU0
    UniProtKB/TrEMBL
    A6JZ10
    Related
    ENSRNOP00000010524.4, ENSRNOT00000010524.5
    Conserved Domains (1) summary
    pfam14909
    Location:11 → 149
    SPATA6; Spermatogenesis-assoc protein 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    131821585..131905011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109229.2 → XP_038965157.1  spermatogenesis-associated protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZST2
    Conserved Domains (1) summary
    pfam14909
    Location:1 → 41
    SPATA6; Spermatogenesis-assoc protein 6

  2. XM_039109230.2 → XP_038965158.1  spermatogenesis-associated protein 6 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MU5.2 GenPept UniProtKB/Swiss-Prot:Q99MU5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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