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Nacc1 nucleus accumbens associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171454, updated on 5-Mar-2024

Summary

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Official Symbol
Nacc1provided by RGD
Official Full Name
nucleus accumbens associated 1provided by RGD
Primary source
RGD:621003
See related
Ensembl:ENSRNOG00000002864 AllianceGenome:RGD:621003
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nac1; Nac-1; Btbd14b
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Orthologous to human NACC1 (nucleus accumbens associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 111.1), Kidney (RPKM 77.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nacc1 in Genome Data Viewer
Location:
19q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40373436..40391351)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23468688..23486528)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25783686..25801526, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nuclear factor I X Neighboring gene uncharacterized LOC120098485 Neighboring gene tRNA methyltransferase 1 Neighboring gene LYL1, basic helix-loop-helix family member Neighboring gene immediate early response 2 Neighboring gene calcium voltage-gated channel subunit alpha1 A Neighboring gene uncharacterized LOC134483326

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activity-dependent subcellular localization of NAC1. Korutla L, et al. Eur J Neurosci, 2005 Jul. PMID 16045493
  2. NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells. Korutla L, et al. Neurosci Res, 2003 May. PMID 12725910
  3. NAC-1, a rat brain mRNA, is increased in the nucleus accumbens three weeks after chronic cocaine self-administration. Cha XY, et al. J Neurosci, 1997 Sep 15. PMID 9278521, Free PMC Article
  4. Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions. Davidson B, et al. Hum Pathol, 2007 Jul. PMID 17391728
  5. NAC1, a cocaine-regulated POZ/BTB protein interacts with CoREST. Korutla L, et al. J Neurochem, 2007 May. PMID 17254023

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. aberrantly regulated NAC1 expression in the mammalian brain may contribute to programmed cell death
    Title: NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells.
  2. The two isoforms of NAC-1 may differentially affect neuronal functions, including the regulation of cocaine-induced locomotion. The longer isoform was the more abundant of the two NAC1 proteins and the ratio between them differed throughout the rat brain.
    Title: Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nucleus accumbens-associated protein 1
Names
BTB (POZ) domain containing 14B
BTB/POZ domain-containing protein 14B
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
nucleus accumbens-1
transcriptional repressor NAC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134413.2 → NP_599240.1  nucleus accumbens-associated protein 1

    See identical proteins and their annotated locations for NP_599240.1

    Status: PROVISIONAL

    Source sequence(s)
    AF015911
    UniProtKB/Swiss-Prot
    O35260
    UniProtKB/TrEMBL
    A6IY85
    Conserved Domains (2) summary
    smart01025
    Location:382 → 460
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3 → 125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    40373436..40391351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277753.1 → XP_063133823.1  nucleus accumbens-associated protein 1 isoform X3

  2. XM_008772346.4 → XP_008770568.1  nucleus accumbens-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_008770568.1

    UniProtKB/Swiss-Prot
    O35260
    UniProtKB/TrEMBL
    A6IY85
    Conserved Domains (2) summary
    smart01025
    Location:382 → 460
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3 → 125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)

  3. XM_006255214.5 → XP_006255276.1  nucleus accumbens-associated protein 1 isoform X1

    Conserved Domains (3) summary
    smart00225
    Location:57 → 148
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart01025
    Location:408 → 486
    BEN; The BEN domain is found in diverse animal proteins
    pfam00651
    Location:46 → 147
    BTB; BTB/POZ domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35260.1 GenPept UniProtKB/Swiss-Prot:O35260

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