Akr1c3 aldo-keto reductase family 1, member C3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr1c3provided by RGD
Official Full Name: aldo-keto reductase family 1, member C3provided by RGD
Primary source: RGD:708428
See related: Ensembl:ENSRNOG00000017531 AllianceGenome:RGD:708428
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Akr1c18
Summary: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to ketone; and female pregnancy. Acts upstream of or within progesterone metabolic process. Located in cytosol and nucleus. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 1184.1) and Kidney (RPKM 75.9) See more
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Genomic context

Location:: 17q12.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (71020884..71037779)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66110970..66127867)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (69761126..69778021)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKR1C3 expression was decreased in the kidneys of L-NAME-induced preeclampsia rats.
Title: Role of AKR1C3 in renal injury and glibenclamide is anti-inflammatory in preeclamptic rats.
Data found that FP localizes in neuronal somata and dendrites but not in ependymal cells, tanycytes, or endothelial cells. Immunohistochemical analysis of serial sections showed the colocalization of FP and PGFS I.
Title: Colocalization of prostaglandin F(2alpha) receptor FP and prostaglandin F synthase-I in the spinal cord.
A strong immunoreactivity was detected not only in classically hormone-associated tissues such as prostate and testis but also in non-hormone-associated tissues such as kidney and bladder in humans and rats.
Title: Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system.
effect of the deciduoma reaction on 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy
Title: Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: effect of the deciduoma reaction.
20alpha-HSD expression and enzymatic activity is closely correlated with the presence of the X-zone.
Title: Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables Delta4-3-oxosteroid 5beta-reductase activity	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables dihydrotestosterone 17-beta-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables geranylgeranyl reductase activity	ISO Inferred from Sequence Orthology more info
enables ketoreductase activity	ISO Inferred from Sequence Orthology more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables phenanthrene 9,10-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticosteroid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to forskolin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to gonadotropin-releasing hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to jasmonic acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prolactin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in farnesol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within parturition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within progesterone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within progesterone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in progesterone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member C18

Names: 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; HSD1; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

NP_612519.1

EC 1.1.1.149

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.