U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd46 CD46 antigen, complement regulatory protein [ Mus musculus (house mouse) ]

Gene ID: 17221, updated on 12-May-2024

Summary

Official Symbol
Cd46provided by MGI
Official Full Name
CD46 antigen, complement regulatory proteinprovided by MGI
Primary source
MGI:MGI:1203290
See related
Ensembl:ENSMUSG00000016493 AllianceGenome:MGI:1203290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcp
Summary
Predicted to enable cadherin binding activity. Predicted to contribute to endopeptidase activity. Predicted to be involved in several processes, including positive regulation of T cell activation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within single fertilization. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and inner acrosomal membrane. Predicted to be active in plasma membrane. Is expressed in testis. Used to study age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 1.4), cortex adult (RPKM 1.4) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
1 H6; 1 98.41 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194721279..194781149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (195038971..195098784, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29b-2 Neighboring gene STARR-seq mESC enhancer starr_03503 Neighboring gene microRNA 29c Neighboring gene complement C3b/C4b receptor 1 like Neighboring gene STARR-positive B cell enhancer ABC_E11117 Neighboring gene STARR-seq mESC enhancer starr_03504 Neighboring gene predicted gene, 32313 Neighboring gene complement receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E11118 Neighboring gene predicted gene, 29726

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of memory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in sequestering of extracellular ligand from receptor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in inner acrosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010778.4NP_034908.1  membrane cofactor protein precursor

    See identical proteins and their annotated locations for NP_034908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AB010919, AC139206, AK006632, BE634816
    Consensus CDS
    CCDS35828.1
    UniProtKB/Swiss-Prot
    O88174, Q9R0R9
    UniProtKB/TrEMBL
    B2RWQ6
    Related
    ENSMUSP00000123931.2, ENSMUST00000162650.8
    Conserved Domains (2) summary
    cd00033
    Location:239294
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:109168
    Sushi; Sushi repeat (SCR repeat)

RNA

  1. NR_132621.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB010919, AC139206, AK006632, BE634816

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194721279..194781149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497236.2XP_006497299.1  membrane cofactor protein isoform X3

    See identical proteins and their annotated locations for XP_006497299.1

    UniProtKB/TrEMBL
    B2RWQ6
    Conserved Domains (1) summary
    PHA02927
    Location:11243
    PHA02927; secreted complement-binding protein; Provisional
  2. XM_006497235.5XP_006497298.1  membrane cofactor protein isoform X2

    UniProtKB/TrEMBL
    B2RWQ6
    Related
    ENSMUSP00000123901.2, ENSMUST00000159563.8
    Conserved Domains (1) summary
    PHA02927
    Location:64296
    PHA02927; secreted complement-binding protein; Provisional
  3. XM_006497234.5XP_006497297.1  membrane cofactor protein isoform X1

    UniProtKB/TrEMBL
    B2RWQ6
    Conserved Domains (1) summary
    PHA02927
    Location:64296
    PHA02927; secreted complement-binding protein; Provisional
  4. XM_006497237.4XP_006497300.1  membrane cofactor protein isoform X3

    See identical proteins and their annotated locations for XP_006497300.1

    UniProtKB/TrEMBL
    B2RWQ6
    Conserved Domains (1) summary
    PHA02927
    Location:11243
    PHA02927; secreted complement-binding protein; Provisional
  5. XM_011238930.4XP_011237232.1  membrane cofactor protein isoform X5

    Conserved Domains (1) summary
    PHA02927
    Location:64235
    PHA02927; secreted complement-binding protein; Provisional
  6. XM_036162529.1XP_036018422.1  membrane cofactor protein isoform X4

    UniProtKB/TrEMBL
    A0A0R4J1X9
    Conserved Domains (1) summary
    PHA02927
    Location:64235
    PHA02927; secreted complement-binding protein; Provisional

RNA

  1. XR_004940718.1 RNA Sequence

  2. XR_373888.5 RNA Sequence

  3. XR_001783154.3 RNA Sequence

  4. XR_373889.5 RNA Sequence