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dhp-1 Dihydropyrimidinase 1 [ Caenorhabditis elegans ]

Gene ID: 172464, updated on 5-May-2024

Summary

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Gene symbol
dhp-1
Gene description
Dihydropyrimidinase 1
Primary source
WormBase:WBGene00000963
Locus tag
CELE_R06C7.3
See related
AllianceGenome:WB:WBGene00000963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Involved in pyrimidine nucleobase catabolic process. Located in nucleus. Is expressed in head; hypodermis; and pharynx. Human ortholog(s) of this gene implicated in dihydropyrimidinase deficiency and purine-pyrimidine metabolic disorder. Orthologous to several human genes including DPYS (dihydropyrimidinase) and DPYSL3 (dihydropyrimidinase like 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (7238994..7243763, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Argonaute protein wago-1 Neighboring gene Chondroitin proteoglycan 3 Neighboring gene Protein N-terminal glutamine amidohydrolase Neighboring gene Adenylosuccinate lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exposing a novel genetic interaction between unc-33/CRMP and hmp-2/β-catenin during Caenorhabditis elegans embryogenesis. Garzanelli J, et al. MicroPubl Biol, 2020 Jul 30. PMID 32760883, Free PMC Article
  2. Cloning and characterization of the Caenorhabditis elegans CeCRMP/DHP-1 and -2; common ancestors of CRMP and dihydropyrimidinase? Takemoto T, et al. Gene, 2000 Dec 31. PMID 11167013
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydropyrimidinase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydropyrimidinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleobase catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleobase catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dihydropyrimidinase 1
NP_001021583.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7238994..7243763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026412.5 → NP_001021583.1  Dihydropyrimidinase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21773, Q9BPU2
    Conserved Domains (2) summary
    PRK09060
    Location:5 → 465
    PRK09060; dihydroorotase; Validated
    cd01314
    Location:5 → 457
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21773.2

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