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Mknk2 MAP kinase-interacting serine/threonine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 17347, updated on 12-May-2024

Summary

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Official Symbol
Mknk2provided by MGI
Official Full Name
MAP kinase-interacting serine/threonine kinase 2provided by MGI
Primary source
MGI:MGI:894279
See related
Ensembl:ENSMUSG00000020190 AllianceGenome:MGI:894279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mnk2; Gprk7; 2010016G11Rik
Summary
The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]
Expression
Broad expression in mammary gland adult (RPKM 326.2), subcutaneous fat pad adult (RPKM 252.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80501152..80512264, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80665318..80676293, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, gamma 2 Neighboring gene predicted gene, 51810 Neighboring gene BTB domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3899 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80141015-80141203 Neighboring gene MOB kinase activator 3A Neighboring gene STARR-positive B cell enhancer ABC_E6884 Neighboring gene IZUMO family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1. Chen BR, et al. J Mol Cell Cardiol, 2022 May. PMID 35235835
  2. MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity. Merrett JE, et al. Biochem J, 2020 Jul 31. PMID 32648926
  3. Mnk kinase pathway: Cellular functions and biological outcomes. Joshi S, et al. World J Biol Chem, 2014 Aug 26. PMID 25225600, Free PMC Article
  4. Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation. Maimon A, et al. Cell Rep, 2014 Apr 24. PMID 24726367
  5. MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling. Huang B, et al. Brain Behav, 2022 Jul. PMID 35608154, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling.
    Title: MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling.
  2. MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1.
    Title: MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1.
  3. Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
    Title: Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
  4. Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
    Title: Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
  5. MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity.
    Title: MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity.
  6. MNK2 governs the macrophage antiinflammatory phenotype.
    Title: MNK2 governs the macrophage antiinflammatory phenotype.
  7. MNK2 plays a role in adipogenesis and/or lipogenesis and in macrophage biology
    Title: MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
  8. Data suggest that Mnk1 and Mnk2 regulate cell migration/wound healing, expression of vimentin, stability of vimentin protein, and binding of eIF4E (eukaryotic translation initiation factor 4E) and Cyfip1 (cytoplasmic FMR1 interacting protein 1).
    Title: The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
  9. Mnk2a directly interacts with and translocates p38alpha-MAPK into the nucleus. Alternatively, Mnk2b does not activate p38-MAPK.
    Title: Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation.
  10. eIF4E phosphorylation is enhanced by Rapamycin, which activates Mnk2a
    Title: Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a).
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 2
Names
G protein-coupled receptor kinase 7
MAP kinase signal-integrating kinase 2
NP_067437.2
XP_006513379.1
XP_017169313.1
XP_036011555.1
XP_036011556.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428628.1 → NP_001415557.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC152410
    UniProtKB/Swiss-Prot
    O08606, Q75PY0, Q8CDB0, Q9D893

  2. NM_001428629.1 → NP_001415558.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AC152410
    UniProtKB/TrEMBL
    A0A0R4IZX7

  3. NM_001428630.1 → NP_001415559.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC152410
    UniProtKB/TrEMBL
    A0A0R4IZX7

  4. NM_021462.5 → NP_067437.2  MAP kinase-interacting serine/threonine-protein kinase 2 isoform a

    See identical proteins and their annotated locations for NP_067437.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC152410
    Consensus CDS
    CCDS24030.2
    UniProtKB/Swiss-Prot
    O08606, Q75PY0, Q8CDB0, Q9D893
    Related
    ENSMUSP00000143508.2, ENSMUST00000200082.5
    Conserved Domains (1) summary
    cl21453
    Location:81 → 368
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80501152..80512264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513316.3 → XP_006513379.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:81 → 368
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036155662.1 → XP_036011555.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

    Related
    ENSMUSP00000003433.7, ENSMUST00000003433.11
    Conserved Domains (1) summary
    cl21453
    Location:34 → 321
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036155663.1 → XP_036011556.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0R4IZX7
    Conserved Domains (1) summary
    cl21453
    Location:34 → 321
    PKc_like; Protein Kinases, catalytic domain

  4. XM_017313824.3 → XP_017169313.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:34 → 321
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDB0.3 GenPept UniProtKB/Swiss-Prot:Q8CDB0

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