gba-1 Putative glucosylceramidase 1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: gba-1
Gene description: Putative glucosylceramidase 1
Primary source: WormBase:WBGene00016335
Locus tag: CELE_C33C12.3
See related: AllianceGenome:WB:WBGene00016335
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA (glucosylceramidase beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See gba-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (2176741..2182510)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C33C12.3 (e-PCR)
- UniSTS:305958

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glucosylceramidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucosylceramidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glucosylceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative glucosylceramidase 1

NP_001040750.1

Confirmed by transcript evidence

NP_001040751.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

2176741..2182510

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047285.3 → NP_001040750.1 Putative glucosylceramidase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040750.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8DZ32, O16580

Conserved Domains (1) summary

pfam02055
Location:23 → 519

Glyco_hydro_30; O-Glycosyl hydrolase family 30
NM_001047286.3 → NP_001040751.1 Putative glucosylceramidase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040751.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16580

Conserved Domains (1) summary

cl23815
Location:1 → 466

Glyco_hydro_30; O-Glycosyl hydrolase family 30