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nep-11 Neprilysin-11 [ Caenorhabditis elegans ]

Gene ID: 173685, updated on 4-Jan-2025

Summary

Official Symbol
nep-11
Official Full Name
Neprilysin-11
Primary source
WormBase:WBGene00017557
Locus tag
CELE_F18A12.8
See related
AllianceGenome:WB:WBGene00017557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to several human genes including ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See nep-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
12
Sequence:
Chromosome: II; NC_003280.10 (3420663..3425533, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FBA_2 domain-containing protein Neighboring gene Transmembrane protein Neighboring gene NEPrilysin metallopeptidase family Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding  
enables metalloendopeptidase activity  
enables metalloendopeptidase activity  
enables metallopeptidase activity  
Process Evidence Code Pubs
involved_in protein processing  
involved_in proteolysis  
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
Neprilysin-11
NP_494538.1
  • Confirmed by transcript evidence
NP_871928.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3420663..3425533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062137.6NP_494538.1  Neprilysin-11 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16796, Q8ITZ3
    Conserved Domains (2) summary
    cd08662
    Location:181845
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:174848
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  2. NM_182128.5NP_871928.1  Neprilysin-11 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871928.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16796
    Conserved Domains (1) summary
    cd08662
    Location:181793
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
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