pho-1 Intestinal acid phosphatase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: pho-1
Gene description: Intestinal acid phosphatase
Primary source: WormBase:WBGene00004020
Locus tag: CELE_EGAP2.3
See related: AllianceGenome:WB:WBGene00004020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Located in membrane raft. Is expressed in intestine. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See pho-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (5233156..5235846, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that pho-1 is required by the maternal intestine to assimilate some nutrient or cleavage product that is subsequently provided to the next generation of embryos.
Title: Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EGAP2.3 (e-PCR)
- UniSTS:313996

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	HDA more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Intestinal acid phosphatase

NP_494983.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5233156..5235846 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062582.5 → NP_494983.1 Intestinal acid phosphatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494983.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19076

Conserved Domains (1) summary

pfam00328
Location:27 → 371

His_Phos_2; Histidine phosphatase superfamily (branch 2)