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let-23 Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase [ Caenorhabditis elegans ]

Gene ID: 174462, updated on 23-Jan-2025

Summary

Official Symbol
let-23
Official Full Name
Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
Primary source
WormBase:WBGene00002299
Locus tag
CELE_ZK1067.1
See related
AllianceGenome:WB:WBGene00002299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables epidermal growth factor receptor activity; lipid binding activity; and molecular function activator activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Is expressed in several structures, including apoptotic cell; epithelial cell; head; somatic nervous system; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including EGFR (epidermal growth factor receptor) and ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See let-23 in Genome Data Viewer
Location:
chromosome: II
Exon count:
20
Sequence:
Chromosome: II; NC_003280.10 (9197512..9207213)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Exocyst complex component 2 Neighboring gene RNA/RNP complex-1-interacting phosphatase homolog Neighboring gene RNA-binding protein sym-2;RRM domain-containing protein Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 151 homolog Neighboring gene ncRNA Neighboring gene tRNA-Tyr Neighboring gene NFX1-type zinc finger-containing protein 1 homolog

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in ERBB signaling pathway  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in determination of adult lifespan PubMed 
involved_in epidermal growth factor receptor signaling pathway PubMed 
involved_in epidermal growth factor receptor signaling pathway PubMed 
involved_in male genitalia development PubMed 
involved_in multicellular organism development  
involved_in negative regulation of apoptotic process  
involved_in nematode larval development PubMed 
involved_in neurogenesis  
involved_in ovulation PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
involved_in positive regulation of vulval development PubMed 
involved_in protein phosphorylation  
involved_in regulation of DNA-templated transcription PubMed 
involved_in reproductive process  
involved_in sleep PubMed 
involved_in uterus development PubMed 
involved_in vulval cell fate specification PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
is_active_in basal plasma membrane  
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in cell-cell junction PubMed 
located_in lateral plasma membrane PubMed 
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane region  
part_of receptor complex  

General protein information

Preferred Names
Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
NP_001129830.1
  • Confirmed by transcript evidence
NP_001129831.1
  • Confirmed by transcript evidence
NP_001300607.1
  • Confirmed by transcript evidence
NP_495962.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9197512..9207213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313678.3NP_001300607.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AX35
    Conserved Domains (7) summary
    smart00219
    Location:8981153
    TyrKc; Tyrosine kinase, catalytic domain
    smart00261
    Location:578625
    FU; Furin-like repeats
    cd00064
    Location:274308
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:229378
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:77205
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:531652
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:8851164
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001136359.5NP_001129831.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129831.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM27
    Conserved Domains (7) summary
    smart00219
    Location:8911146
    TyrKc; Tyrosine kinase, catalytic domain
    smart00261
    Location:571618
    FU; Furin-like repeats
    cd00064
    Location:267301
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:222371
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:70198
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:524645
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:8781157
    PKc_like; Protein Kinases, catalytic domain
  3. NM_063561.5NP_495962.2  Receptor tyrosine-protein kinase let-23 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495962.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P24348
    Conserved Domains (7) summary
    smart00219
    Location:8861141
    TyrKc; Tyrosine kinase, catalytic domain
    smart00261
    Location:566613
    FU; Furin-like repeats
    cd00064
    Location:262296
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:217366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:65193
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:519640
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:8731152
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001136358.4NP_001129830.1  receptor protein-tyrosine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129830.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM28
    Conserved Domains (7) summary
    smart00219
    Location:8251080
    TyrKc; Tyrosine kinase, catalytic domain
    smart00261
    Location:505552
    FU; Furin-like repeats
    cd00064
    Location:201235
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:156305
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4132
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:458579
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:8121091
    PKc_like; Protein Kinases, catalytic domain
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