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sqv-8 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 [ Caenorhabditis elegans ]

Gene ID: 174517, updated on 9-Dec-2024

Summary

Official Symbol
sqv-8
Official Full Name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
Primary source
WormBase:WBGene00005026
Locus tag
CELE_ZK1307.5
See related
AllianceGenome:WB:WBGene00005026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables glucuronosyltransferase activity. Involved in several processes, including chondroitin sulfate biosynthetic process; egg-laying behavior; and vulval development. Located in membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; Larsen-like syndrome B3GAT3 type; and schizophrenia. Orthologous to several human genes including B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See sqv-8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (9647878..9649367)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glucosidase 2 subunit beta Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Anaphase-promoting complex subunit 4-like WD40 domain-containing protein Neighboring gene Coiled-coil domain-containing protein 130 homolog Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Pathways from PubChem

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in Golgi membrane  
located_in membrane PubMed 
located_in membrane  

General protein information

Preferred Names
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
NP_496076.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9647878..9649367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063675.6NP_496076.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496076.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09363
    Conserved Domains (2) summary
    cd00218
    Location:97327
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
    cl11433
    Location:1586
    DivIC; Septum formation initiator
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