sqv-8 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 [Caenorhabditis elegans] - Gene

Summary

Gene symbol: sqv-8
Gene description: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
Primary source: WormBase:WBGene00005026
Locus tag: CELE_ZK1307.5
See related: AllianceGenome:WB:WBGene00005026
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables glucuronosyltransferase activity. Involved in several processes, including chondroitin sulfate biosynthetic process; oviposition; and pharynx development. Located in membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; Larsen-like syndrome B3GAT3 type; and schizophrenia. Orthologous to several human genes including B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8

NP_496076.1

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The following sections contain reference sequences that belong to a specific genome build. Explain