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Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 [ Mus musculus (house mouse) ]

Gene ID: 17463, updated on 5-Mar-2024

Summary

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Official Symbol
Psmd7provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7provided by MGI
Primary source
MGI:MGI:1351511
See related
Ensembl:ENSMUSG00000039067 AllianceGenome:MGI:1351511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mov34; Mov-34
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including brain; liver; metanephros; placenta; and spleen. Orthologous to human PSMD7 (proteasome 26S subunit, non-ATPase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 54.8), liver E14 (RPKM 52.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Psmd7 in Genome Data Viewer
Location:
8 D3; 8 54.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108307012..108315114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107580380..107588482, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_22610 Neighboring gene predicted gene, 51547 Neighboring gene STARR-positive B cell enhancer ABC_E11397 Neighboring gene microRNA 140 Neighboring gene STARR-seq mESC enhancer starr_22613 Neighboring gene STARR-seq mESC enhancer starr_22614 Neighboring gene STARR-seq mESC enhancer starr_22615 Neighboring gene STARR-seq mESC enhancer starr_22616 Neighboring gene predicted gene 8940 Neighboring gene STARR-seq mESC enhancer starr_22618 Neighboring gene predicted gene, 42040 Neighboring gene predicted gene, 39242

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mov34 protein from mouse brain interacts with the 3' noncoding region of Japanese encephalitis virus. Ta M, et al. J Virol, 2000 Jun. PMID 10799585, Free PMC Article
  2. Molecular cloning and expression of subunit 12: a non-MCP and non-ATPase subunit of the 26 S protease. Dubiel W, et al. FEBS Lett, 1995 Apr 17. PMID 7729561
  3. The murine Mov-34 gene: full-length cDNA and genomic organization. Gridley T, et al. Genomics, 1991 Nov. PMID 1837787
  4. cDNA cloning of p40, a regulatory subunit of the human 26S proteasome, and a homolog of the Mov-34 gene product. Tsurumi C, et al. Biochem Biophys Res Commun, 1995 May 16. PMID 7755639
  5. Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death. Soriano P, et al. Genes Dev, 1987 Jun. PMID 2824282

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.
    Title: Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 7
Names
26S proteasome regulatory subunit S12
26S proteasome regulatory subunit rpn8
proteasome subunit p40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010817.2 → NP_034947.1  26S proteasome non-ATPase regulatory subunit 7

    See identical proteins and their annotated locations for NP_034947.1

    Status: VALIDATED

    Source sequence(s)
    AC134855, AW492454, BC130014
    Consensus CDS
    CCDS22650.1
    UniProtKB/Swiss-Prot
    P26516, Q3TW61, Q8C0I8
    UniProtKB/TrEMBL
    A1L3B8
    Related
    ENSMUSP00000041968.5, ENSMUST00000044106.6
    Conserved Domains (2) summary
    cd08062
    Location:7 → 285
    MPN_RPN7_8; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8
    PLN03246
    Location:6 → 284
    PLN03246; 26S proteasome regulatory subunit; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    108307012..108315114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26516.2 GenPept UniProtKB/Swiss-Prot:P26516

Gene LinkOut

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