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nep-1 Neprilysin-1 [ Caenorhabditis elegans ]

Gene ID: 174787, updated on 4-Jan-2025

Summary

Official Symbol
nep-1
Official Full Name
Neprilysin-1
Primary source
WormBase:WBGene00013926
Locus tag
CELE_ZK20.6
See related
AllianceGenome:WB:WBGene00013926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in RIH and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to several human genes including ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See nep-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (11654208..11657179, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UV excision repair protein RAD23 Neighboring gene 26S proteasome non-ATPase regulatory subunit 8 Neighboring gene ncRNA Neighboring gene Transcription-associated protein 1

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding  
enables metalloendopeptidase activity  
enables metalloendopeptidase activity  
enables metallopeptidase activity  
Process Evidence Code Pubs
involved_in protein processing  
involved_in proteolysis  
Component Evidence Code Pubs
located_in membrane  
is_active_in plasma membrane  

General protein information

Preferred Names
Neprilysin-1
NP_496490.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    11654208..11657179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064089.7NP_496490.2  Neprilysin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496490.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18673, Q23453
    Conserved Domains (1) summary
    cd08662
    Location:85751
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
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