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ida-1 Receptor-type tyrosine-protein phosphatase-like ida-1 [ Caenorhabditis elegans ]

Gene ID: 175807, updated on 4-Jan-2025

Summary

Official Symbol
ida-1
Official Full Name
Receptor-type tyrosine-protein phosphatase-like ida-1
Primary source
WormBase:WBGene00002048
Locus tag
CELE_B0244.2
See related
AllianceGenome:WB:WBGene00002048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Involved in positive regulation of anterior/posterior axon guidance; positive regulation of neurotransmitter secretion; and ventral cord development. Located in dense core granule and synapse. Is expressed in several structures, including buccal cavity; egg-laying apparatus; neurons; preanal ganglion; and somatic nervous system. Used to study Parkinson's disease and diabetes mellitus. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to several human genes including PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See ida-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (5755539..5765816)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein;Putative G-protein coupled receptor B0244.4 Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene VWFA domain-containing protein;von Willebrand factor type A domain protein Neighboring gene DNA polymerase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in axon  
located_in cell projection  
located_in cytoplasmic vesicle  
located_in cytoplasmic vesicle membrane  
located_in dendrite  
located_in dense core granule PubMed 
located_in membrane  
located_in perikaryon  
is_active_in secretory granule  
located_in secretory granule  
is_active_in synapse  
located_in synapse PubMed 
located_in trans-Golgi network transport vesicle PubMed 

General protein information

Preferred Names
Receptor-type tyrosine-protein phosphatase-like ida-1
NP_498245.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5755539..5765816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065844.7NP_498245.2  Receptor-type tyrosine-protein phosphatase-like ida-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498245.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGJ5
    Conserved Domains (1) summary
    cd00047
    Location:529755
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
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