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glr-1 Glutamate receptor 1 [ Caenorhabditis elegans ]

Gene ID: 176204, updated on 23-Jan-2025

Summary

Official Symbol
glr-1
Official Full Name
Glutamate receptor 1
Primary source
WormBase:WBGene00001612
Locus tag
CELE_C06E1.4
See related
AllianceGenome:WB:WBGene00001612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables enzyme binding activity and glutamate-gated receptor activity. Involved in several processes, including forward locomotion; learning or memory; and positive regulation of backward locomotion. Located in several cellular components, including neuron projection membrane; perinuclear endoplasmic reticulum; and postsynaptic membrane. Part of ionotropic glutamate receptor complex. Is expressed in ganglia; neurons; and ventral nerve cord. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Huntington's disease; epilepsy (multiple); intellectual disability (multiple); and schizophrenia. Orthologous to several human genes including GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See glr-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
14
Sequence:
Chromosome: III; NC_003281.10 (8584163..8588642, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Dual oxidase maturation factor 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fungus-induced protein 3

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMPA glutamate receptor activity PubMed 
enables enzyme binding PubMed 
enables glutamate receptor activity  
enables glutamate-gated receptor activity PubMed 
enables ligand-gated monoatomic ion channel activity  
enables monoatomic ion channel activity  
enables protein binding PubMed 
enables signaling receptor activity  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
Process Evidence Code Pubs
involved_in adult locomotory behavior PubMed 
involved_in associative learning PubMed 
involved_in cell surface receptor signaling pathway  
involved_in feeding behavior PubMed 
involved_in forward locomotion PubMed 
involved_in habituation PubMed 
involved_in hyperosmotic response PubMed 
involved_in ionotropic glutamate receptor signaling pathway PubMed 
involved_in modulation of chemical synaptic transmission  
involved_in monoatomic ion transmembrane transport  
involved_in monoatomic ion transport  
involved_in positive regulation of backward locomotion PubMed 
involved_in positive regulation of forward locomotion PubMed 
involved_in regulation of backward locomotion PubMed 
involved_in regulation of backward locomotion PubMed 
involved_in regulation of postsynaptic membrane potential  
involved_in response to mechanical stimulus PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in sensory perception of bitter taste PubMed 
involved_in short-term memory PubMed 
involved_in synaptic transmission, glutamatergic  
involved_in synaptic transmission, glutamatergic PubMed 
involved_in thigmotaxis PubMed 
Items 1 - 20 of 26
Component Evidence Code Pubs
located_in cell projection  
located_in cell surface PubMed 
located_in dendrite PubMed 
located_in dendrite  
located_in dendrite PubMed 
located_in endoplasmic reticulum  
located_in endosome  
part_of ionotropic glutamate receptor complex PubMed 
part_of ionotropic glutamate receptor complex PubMed 
located_in membrane  
located_in neuron projection PubMed 
located_in neuron projection membrane PubMed 
located_in neuronal cell body PubMed 
located_in perikaryon  
located_in perinuclear endoplasmic reticulum PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in postsynaptic density PubMed 
is_active_in postsynaptic density membrane  
located_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
located_in postsynaptic membrane PubMed 
located_in recycling endosome  
located_in synapse PubMed 
located_in synapse  
Items 1 - 20 of 26

General protein information

Preferred Names
Glutamate receptor 1
NP_498887.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8584163..8588642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066486.8NP_498887.2  Glutamate receptor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498887.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34299, Q17363
    Conserved Domains (4) summary
    cd06380
    Location:10439
    PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
    pfam00060
    Location:593867
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:44417
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:457832
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
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