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gly-5 Polypeptide N-acetylgalactosaminyltransferase 5 [ Caenorhabditis elegans ]

Gene ID: 176736, updated on 22-May-2024

Summary

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Gene symbol
gly-5
Gene description
Polypeptide N-acetylgalactosaminyltransferase 5
Primary source
WormBase:WBGene00001630
Locus tag
CELE_Y39E4B.12
See related
AllianceGenome:WB:WBGene00001630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including POC1B-GALNT4 (POC1B-GALNT4 readthrough) and GALNT12 (polypeptide N-acetylgalactosaminyltransferase 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See gly-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (13187390..13204897)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SNAPc (Small Nuclear RNA Activating Complex) homolog Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene UDG domain-containing protein Neighboring gene Tetraspanin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. Hagen FK, et al. J Biol Chem, 1998 Apr 3. PMID 9525933
  2. The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Wang H, et al. Mol Biol Cell, 2005 Sep. PMID 15987734, Free PMC Article
  3. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. Schwientek T, et al. J Biol Chem, 2002 Jun 21. PMID 11925450
  4. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  5. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via threonine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Polypeptide N-acetylgalactosaminyltransferase 5
NP_001022852.1
  • Confirmed by transcript evidence
NP_001370120.1
  • Confirmed by transcript evidence
NP_001379253.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13187390..13204897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027681.9 → NP_001022852.1  Polypeptide N-acetylgalactosaminyltransferase 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95ZJ1
    Conserved Domains (4) summary
    cd02510
    Location:178 → 477
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:173 → 448
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:490 → 607
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:488 → 605
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_001383020.1 → NP_001370120.1  Polypeptide N-acetylgalactosaminyltransferase 5 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd02510
    Location:178 → 477
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:488 → 604
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. NM_001392225.1 → NP_001379253.1  Polypeptide N-acetylgalactosaminyltransferase 5 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61391, O61392, O61393, Q95ZJ1, Q95ZJ2, Q9U2J8
    Conserved Domains (2) summary
    cd02510
    Location:178 → 477
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:488 → 607
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95ZJ1.2

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