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cpi-1 Cystatin cpi-1 [ Caenorhabditis elegans ]

Gene ID: 177372, updated on 4-Jan-2025

Summary

Official Symbol
cpi-1
Official Full Name
Cystatin cpi-1
Primary source
WormBase:WBGene00000535
Locus tag
CELE_K08B4.6
See related
AllianceGenome:WB:WBGene00000535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cysteine-type endopeptidase inhibitor activity. Predicted to be active in cytoplasm; extracellular space; and vesicle. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy; age related macular degeneration 11; and ectodermal dysplasia 15. Orthologous to several human genes including CST3 (cystatin C); CST4 (cystatin S); and CST1 (cystatin SN). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See cpi-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (6092603..6093680, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cystatin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Suppressor of hairless protein homolog Neighboring gene ncRNA

Interactions

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in extracellular space  
is_active_in vesicle  

General protein information

Preferred Names
Cystatin cpi-1
NP_500915.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6092603..6093680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068514.6NP_500915.1  Cystatin cpi-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500915.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDZ9
    Conserved Domains (1) summary
    smart00043
    Location:20124
    CY; Cystatin-like domain
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